Project Grant K23DK146184
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Boston Medical Center Corporation $918,576 on June 24, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the mechanistic link between sociodemographic stressors and chronic kidney disease and end-stage kidney disease incidence in Black women. The research utilizes the Black Women's Health Study to model how cumulative allostatic load — chronic stress and...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the Veterans Medical Research Foundation of San Diego $383,098 on September 2, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The recipient will conduct research into kidney tubule dysfunction in APOL1-associated chronic kidney disease, with focus on developing and validating tubular biomarkers that capture kidney functions—nutrient reabsorption and toxin...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Duke University $1,636,543 on March 17, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the role of the ubiquitin editor A20 in regulating sodium transport and the hypertensive response through selective actions in kidney epithelial cells and tubules. The research addresses the mechanisms through which A20 suppresses inflammatory cytokines that modulate...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Pennsylvania $691,758 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate DCLK1 isoform switching and its role in proximal tubule injury during kidney disease progression. The award funds basic research to understand how DCLK1 regulates inflammation and DNA damage response pathways in injured proximal tubule cells, which...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Duke University $179,250 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to promote evidence-based chronic kidney disease care among Hispanic and Latino individuals with type 2 diabetes. Duke will conduct research aimed at identifying multi-level perspectives on chronic kidney disease screening and treatment through interviews with Hispanic patients...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Duke University $832,783 under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) on February 1, 2026, to define cellular and molecular signatures of inflammation in people with HIV on antiretroviral therapy that promote chronic kidney disease. The research employs a dual-cohort approach: retrospective analysis of plasma inflammatory endotypes in aging people with HIV (age 50 and...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Duke University $807,500 on August 15, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The project, titled "Decoding the Logic of Metabolite Pool Size Control," develops an integrated metabolic control discovery platform to understand the molecular mechanisms that regulate metabolite concentrations in cells. The research will systematically discover molecular...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Alabama at Birmingham $650,509 on August 20, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the myeloid ferritin–CXCL3 axis as a driver of acute kidney injury (AKI) progression to chronic kidney disease. The research leverages novel transgenic mice with targeted deletion of ferritin genes in myeloid cells to determine whether myeloid...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Pittsburgh $812,862 on June 12, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to identify novel biomarkers of early progressive kidney function decline in type 1 diabetes. The research will use urinary and plasma peptidomics—analysis of synthesized peptides and protein degradation fragments—to discover prognostic markers that predict diabetic...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Emory University $1.594 million on September 15, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct a prospective longitudinal cohort study characterizing quality-of-life experiences among 221 home dialysis patients and their family caregivers. The study will examine how patients and caregivers incorporate peritoneal dialysis and home hemodialysis into daily...
The National Institute of Diabetes and Digestive and Kidney Diseases awarded Duke University $381,060 on August 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The project examines chronic stress as a risk factor for the development and progression of chronic kidney disease and identifies two physiological pathways linking stress to kidney disease: elevation of systemic inflammatory cytokines (IL-6 and CRP) and enhanced autonomic nervous system activity (including restricted heart rate variability and reduced sleep duration or quality). The research uses data from two separate studies—the Reasons for Geographic and Racial Differences (REGARDS) population-level retrospective study and a subsample from the Community Apolipoprotein L1 (APOL1) Research Engagement (CARE) prospective, longitudinal study—with different samples, measures, and data collection methods to support data reproducibility. The project also investigates chronic stress as an upstream factor in APOL1-mediated kidney disease, probing how stress-induced elevation of inflammatory cytokines may increase kidney expression of APOL1 and result in chronic kidney disease among individuals with high-risk genotypes. Work is performed in Durham, North Carolina. The period of performance runs from August 1, 2026, through April 30, 2031. The assistance type is a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 8/27/26 | ||
| Not listed | $190.5k | 7/28/26 |