Project Grant K23DK146170
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Duke University $381,060 on August 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The project examines chronic stress as a risk factor for the development and progression of chronic kidney disease and identifies two physiological pathways linking stress to kidney disease: elevation of systemic inflammatory cytokines (IL-6 and CRP) and enhanced autonomic nervous...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Duke University $832,783 under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) on February 1, 2026, to define cellular and molecular signatures of inflammation in people with HIV on antiretroviral therapy that promote chronic kidney disease. The research employs a dual-cohort approach: retrospective analysis of plasma inflammatory endotypes in aging people with HIV (age 50 and...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Duke University $1,636,543 on March 17, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the role of the ubiquitin editor A20 in regulating sodium transport and the hypertensive response through selective actions in kidney epithelial cells and tubules. The research addresses the mechanisms through which A20 suppresses inflammatory cytokines that modulate...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Duke University $807,500 on August 15, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The project, titled "Decoding the Logic of Metabolite Pool Size Control," develops an integrated metabolic control discovery platform to understand the molecular mechanisms that regulate metabolite concentrations in cells. The research will systematically discover molecular...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The University of Texas Southwestern Medical Center $767,831 on April 20, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to evaluate community-based culinary medicine interventions for chronic kidney disease prevention in health disparity populations. The project, titled "Food as Medicine to Reduce CKD Burden in Health Disparity Populations (FAME to Reduce...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the Veterans Medical Research Foundation of San Diego $383,098 on September 2, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The recipient will conduct research into kidney tubule dysfunction in APOL1-associated chronic kidney disease, with focus on developing and validating tubular biomarkers that capture kidney functions—nutrient reabsorption and toxin...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Emory University $1.594 million on September 15, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct a prospective longitudinal cohort study characterizing quality-of-life experiences among 221 home dialysis patients and their family caregivers. The study will examine how patients and caregivers incorporate peritoneal dialysis and home hemodialysis into daily...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Duke University $790,119 on August 26, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate how memory formation in adipose tissue influences metabolic outcomes in obesity. The project, titled "Establishing Memory in Adipose Tissue Influences Future Metabolic Outcomes in Obesity," examines the mechanisms that drive divergent remodeling of white...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Boston Medical Center Corporation $388,294 on February 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to develop and test first-person storytelling video narratives tailored for Spanish-speaking patients with advanced kidney disease. The project addresses a documented gap in culturally and linguistically concordant kidney replacement therapy (KRT) education for...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded $825,255 to The University of Texas Health Science Center at San Antonio on April 15, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to identify and validate metabolite markers of diabetic kidney disease in type 1 diabetes. The award funds research integrating single-cell RNA sequencing, spatial transcriptomics, and metabolomics to map cellular sources of adenine, an...
The National Institute of Diabetes and Digestive and Kidney Diseases awarded Duke University $179,250 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to promote evidence-based chronic kidney disease care among Hispanic and Latino individuals with type 2 diabetes. Duke will conduct research aimed at identifying multi-level perspectives on chronic kidney disease screening and treatment through interviews with Hispanic patients and caregivers; present these findings to a community advisory board to optimize integration of community health workers into the "Rinones Dulces" ("Sweet Kidneys") clinician-facing intervention; and pilot test the enhanced intervention in a Hispanic-serving health system to assess feasibility, accessibility, and clinical outcomes. The original "Rinones Dulces" intervention increased urine albumin-to-creatinine ratio screening by 59 percent and SGLT2 inhibitor or GLP-1 receptor agonist prescribing by 37 percent in prior pilot work. The research addresses barriers to optimal care including high co-pays, time constraints, language barriers, and patient hesitancy regarding medication side effects by leveraging community health workers as trusted community members who share language and culture with patients. Work will be performed in Durham, North Carolina, with a period of performance from September 1, 2026, through May 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $179.3k | 8/13/26 |