This federal Project Grant award of $671,986 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research to strengthen the evidence-base for medication prescribing in older adults with chronic kidney disease (CKD). The primary objectives are to: 1) Evaluate the effectiveness of renoprotective therapies, such as angiotensin converting enzyme inhibitors (ACEIs) and sodium-glucose...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $192,215 to The Regents of the University of California, San Francisco (UCSF) to assess patient-centric factors and enhance risk communication to improve treatment persistence for sodium-glucose cotransporter 2 inhibitors (SGLT2i) and glucagon-like peptide 1 receptor agonists...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) will provide $596,345 to Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) to investigate the molecular mechanisms underlying diabetic renal hypertrophy and its impact on acute kidney injury (AKI) susceptibility and severity in diabetes. The key objectives are to: (1) determine...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research program, will support a translational research study to investigate the role of the gut microbiome in the pathogenesis of sepsis-associated acute kidney injury (AKI). The $126,846 award, effective December 24, 2024 through June 30, 2026, will enable the principal investigator at the University of Michigan to: 1)...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will fund a multicenter, cluster-randomized, open-label, multiple-crossover trial to compare the use of norepinephrine versus phenylephrine as the first-line vasopressor infusion to prevent postoperative acute kidney injury in adult patients undergoing major non-cardiac surgery under general...
This $531,999 federal Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847), will support research at Washington University on the role of alternative splicing in the progression of diabetic kidney disease (DKD). The research aims to: 1) Define and validate the spectrum of alternative splicing in DKD and the impact of sodium-glucose cotransporter 2 inhibitor (SGLT2i) treatment using long-read RNA sequencing; 2) Test the hypothesis...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $199,999 to the University of Florida to develop innovative artificial intelligence (AI)-based methods to support the discovery of potent, orally available small-molecule heparanase inhibitors. The goal is to evaluate these novel heparanase inhibitors in murine models as a...
This $199,990 Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research at The Ohio State University to investigate the role of the transcriptional corepressor CTBP2 as a metabolic sensor in acute kidney injury (AKI). The key objectives are to: 1) examine how acetylation regulates the nuclear localization and activation...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) is funding research to develop a therapeutic approach using dicarboxylic acids (DCAs) to prevent and treat acute kidney injury (AKI) and limit progression to chronic kidney disease (CKD). The $645,599 award to the University of Pittsburgh is supporting preclinical studies in animal models...
This federal Project Grant award of $117,000 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports a systems biology research project conducted by the Regents of the University of Michigan. The key objectives are to: 1) Validate predicted transcription factor binding motifs related to the hypoxia-inducible factor 1-alpha (HIF1A) in areas of open chromatin using multiomics data, and 2)...