Federal Grant Award Summary

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $203,244 Project Grant to The Regents of the University of California, San Francisco (UCSF) effective July 1, 2026, through May 31, 2031, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award supports research to characterize real-world variation in pediatric intestinal failure treatment strategies and outcomes, leveraging the multicenter prospective International Intestinal Failure Registry. The project will assess center-level variation in the use of nutritional, pharmacologic, and surgical therapeutic interventions—including polymeric formula, teduglutide, and bowel-lengthening procedures—among pediatric patients with short bowel syndrome and intestinal failure (n>400), while evaluating associations between individual therapies and clinical outcomes such as time to parenteral nutrition discontinuation and patient growth.

This research addresses a significant clinical gap in evidence-based guidance for achieving enteral autonomy in pediatric intestinal failure, a rare but severe condition affecting approximately 1 in 5,000 live births in the United States with high morbidity and mortality rates. By establishing evidence-based treatment protocols through real-world data analysis, the project aims to standardize clinical practices across treatment centers and improve outcomes for children dependent on parenteral nutrition support.