Project Grant R01DK143079
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $441,375 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Children's Hospital Medical Center (UEI JZD1HLM2ZU83) to conduct research on the "Transcriptional Mechanisms of Chronic Inflammation in Genetically Diverse Tissue Macrophages." The project will focus on understanding the genetic factors and regulatory mechanisms that contribute to the development of metabolic...
- This $814,790 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to uncover the immune mechanisms underlying hepatitis B virus (HBV) surface antigen clearance, which can lead to a clinical cure for chronic HBV infection. The principal investigators at the University of California, San Francisco (UCSF) will leverage mouse models and clinical samples from HBV patients to conduct a...
- This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is providing $173,664 to The Regents of the University of California, San Francisco (UCSF) to conduct research on "Molecular Characterization of Ascites Fluid to Identify Drivers of Infection in Patients with Decompensated Cirrhosis." The project aims to apply metagenomic...
- This $2,971,227 federal Project Grant, awarded on September 4, 2025 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to investigate the role of fatty acids in regulating cellular metabolism and protein synthesis in the context of fasting, inflammation, and metabolic diseases. The research aims to uncover novel signaling pathways through which fatty...
- This federal Project Grant award from the Department of Defense's Military Medical Research and Development program (CFDA 12.420) provides $1,292,000.00 to the University of California, San Francisco (UCSF) to conduct in vivo mechanistic characterization of the angiogenic immune checkpoint in liver cancer. The research aims to transform healthcare for Service Members and the American public through innovative and impactful biomedical investigations. The 4-year research project will involve...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $433,125.00 in funding to the University of California, Los Angeles (UCLA) to investigate the role of TIM-4 signaling in regulating immune responses, phagocytosis, and hepatocellular damage in non-alcoholic steatohepatitis (NASH) liver transplant ischemia/reperfusion injury. The research aims to determine if TIM-4-derived foamy macrophages in...
- This $3,255,832 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) will support research at the University of Chicago to investigate the role of macrophages in weight loss-induced metabolic health and adipose tissue inflammation resolution. The project aims to determine the phenotype, function, and transcriptome of visceral and subcutaneous adipose tissue macrophages across mouse and human models, as well as test strategies like cell...
- This $786,216 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research on post-transcriptional regulation of hepatokines and their impact on systemic metabolism. The University of California, Los Angeles is conducting this research to investigate a novel mechanism by which the liver uses RNA-binding proteins to control the...
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 - Allergy and Infectious Diseases Research, provides $205,999 over 5 years to support a research program focused on understanding maternal-fetal immune interactions and the potential impact of environmental exposures on susceptibility to infection during pregnancy. The primary goal is to develop a cohort of young investigators with the skills to conduct high-quality...
- The Project Grant award of $189,376 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855) supports research to unravel the interactions between skin microbiota and the immune system that drive early-life commensal tolerance. The research aims to better understand the mechanisms by which conserved microbial signals, specifically those recognized by Toll-like Receptor 2 (TLR2), promote the...
This $3,176,680 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research at the University of California, San Francisco (UCSF) to investigate the role of the scavenger receptor MARCO in regulating the balance between regulatory and immunogenic immune responses in the neonatal liver. The research aims to elucidate how MARCO expressed on liver macrophages restricts anti-inflammatory functions and impacts outcomes in a mouse model of perinatal liver inflammation. The 4-year project, commencing on September 15, 2025, will utilize novel tools to quantify the effects of MARCO on regulatory immune responses mediated by the anti-inflammatory cytokine interleukin-10. The findings are expected to enhance understanding of the mechanisms maintaining immune homeostasis in the perinatal liver, which is critical for preventing chronic viral infection or neonatal cirrhosis due to dysregulated immunity.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.2m | 9/11/25 |