This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $516,648 to The Leland Stanford Junior University to conduct research on understanding the mechanisms by which microbially derived metabolites regulate host gut inflammation. The award period runs from August 28, 2024 to February 28, 2027. The research aims to determine the regulatory...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) provides $1,739,177 to The Leland Stanford Junior University to conduct research on the role of impaired cellular RNA editing in the etiology of inflammatory bowel disease (IBD). The research aims to: Leverage genetic data to prioritize double-stranded RNA (dsRNA) loci associated with IBD susceptibility and systematically assess how risk and protective alleles affect dsRNA editing....
This Project Grant award of $790,359.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research to develop a targeted probiotic yeast therapeutic for treating inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis. The award will fund the design, characterization, and optimization of a bioengineered Saccharomyces boulardii yeast that can secrete nanobody...
This federal Project Grant award of $151,643, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research on developing and evaluating Proteolysis Targeting Chimeras (PROTACs) to stabilize hypoxia-inducible factors (HIFs) as a potential therapeutic approach for inflammatory bowel disease (IBD). The principal investigator, Dr. Ornelas Sanchez, and his...
This $188,538 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research at Northwestern University to develop predictive modeling of chromatin packing domains for personalized biomarker discovery in ulcerative colitis. The goal is to establish a framework linking transcriptomic states with chromatin structure to advance biomarker development. The research project...
This $548,802 Project Grant, awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research) on September 19, 2024, aims to improve the colonization and engraftment of the live biotherapeutic product Escherichia coli Nissle 1917 (ECN) in the presence of phage predation. The funding will support research by Ancilia Biosciences Inc. to engineer a CRISPR-Cas system that can provide phage immunity to ECN,...
This federal Project Grant award of $1,255,725.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) aims to advance defined live biotherapeutic products (LBPs) for the treatment of recurrent Clostridioides difficile infection (rCDI) and ulcerative colitis. The key objectives are to: 1) Develop a solid-state fermentation platform to increase the scale and throughput of...
This federal Project Grant award of $645,617 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research at the Icahn School of Medicine at Mount Sinai to understand hematopoietic stem cell dysfunction in refractory Crohn's disease. The key objectives are to (1) profile hematopoietic stem cell populations associated with refractory Crohn's disease, (2) characterize hematopoietic stem cell...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $859,704 to support research on how the endoplasmic reticulum (ER) protein AGR2 regulates host-microbe interactions and inflammatory responses in Crohn's disease. The research aims to elucidate the cellular and molecular mechanisms by which AGR2 deficiency leads to ER stress, bacterial dysbiosis, and...
This $202,728 federal Project Grant awarded by the National Science Foundation's (NSF) Computer and Information Science and Engineering (CISE) program funds a collaborative research project to develop a theragnostic (therapeutic and diagnostic) system for inflammatory bowel diseases (IBD). The project aims to integrate data science, synthetic biology, and additive manufacturing to model the complex interplay of host, microbial, and environmental factors in IBD, and develop an engineered...