This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports a 5-year research program focused on defining novel neuro-immune pathways that regulate gut physiology. The $168,296 award to Weill Medical College of Cornell University aims to investigate the role of enzymes in group 3 innate lymphoid cells (ILC3s) and their impact on inflammatory bowel disease (IBD) and...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $163,825 to The Regents of the University of Colorado, doing business as the University of Colorado-Denver, to study the role of AXL signaling in intestinal fibrosis associated with Crohn's disease. The research aims to unravel the intricacies of the GAS6/AXL signaling pathway and how...
This Project Grant award of $790,359.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research to develop a targeted probiotic yeast therapeutic for treating inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis. The award will fund the design, characterization, and optimization of a bioengineered Saccharomyces boulardii yeast that can secrete nanobody...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $516,648 to The Leland Stanford Junior University to conduct research on understanding the mechanisms by which microbially derived metabolites regulate host gut inflammation. The award period runs from August 28, 2024 to February 28, 2027. The research aims to determine the regulatory...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $228,948.00 to Weill Medical College of Cornell University to investigate how the neuropeptide adrenomedullin 2 (ADM2) regulates intestinal inflammation and tissue protection through its effects on group 2 innate lymphoid cells (ILC2s). The research aims to: 1) Test if enteric neurons modulate ADM2 expression...
This $1,060,675.00 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research at the University of Arizona focused on understanding how the pattern recognition receptor Absent in Melanoma 2 (AIM2) impacts intestinal stem cell differentiation and immune responses during inflammation. The project will utilize tissue-specific animal models, intestinal epithelial organoid...
This Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $502,752 in funding to Washington University to conduct a 5-year research program focused on understanding how endoplasmic reticulum (ER) stress controls innate lymphoid cells in intestinal inflammation and inflammatory bowel disease. The research, led by Dr. Siyan Cao, aims to elucidate the mechanistic role of...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is providing $220,930.00 to The Medical University of South Carolina to conduct research on elucidating the role of myosin 5B in microvilli assembly and in the setting of inflammation, with a focus on Crohn's disease. The research aims to investigate how myosin 5B regulates microvilli...
This Project Grant award of $758,542 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research supports research to determine the protective functional impact mediated by the protein POP3 on intestinal homeostasis and inflammatory bowel disease (IBD). The research aims to elucidate the underlying molecular mechanisms by which POP3 promotes a unique type I interferon signature to shape the...
This federal Project Grant award of $645,617 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research at the Icahn School of Medicine at Mount Sinai to understand hematopoietic stem cell dysfunction in refractory Crohn's disease. The key objectives are to (1) profile hematopoietic stem cell populations associated with refractory Crohn's disease, (2) characterize hematopoietic stem cell...