Project Grant K23DK138288
- This federal Project Grant award of $465,444.00, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to investigate how commensal fungi in the gut can promote intestinal wound repair. The research aims to mechanistically understand how fungi modulate epithelial cells and fibroblasts to enhance crypt regeneration, with a focus on identifying the...
- This $2,842,245 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to elucidate the role of intestinal epithelial cell (IEC) injury pathways in governing anti-TNF therapy effectiveness for ulcerative colitis. The project aims to identify predictive biomarkers in formalin-fixed, paraffin-embedded (FFPE) patient biopsies that...
- This federal Project Grant award of $790,359, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to develop a targeted probiotic yeast therapeutic for treating inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis. The research project aims to design, characterize, and optimize a fibronectin-targeting, nanobody...
- The University of Chicago was awarded a $184,572 Project Grant by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) to conduct research on characterizing the transmural nature of ulcerative colitis and its associated disease-related outcomes using intestinal ultrasound. The project aims to identify new therapeutic targets and endpoints in clinical trials by determining the predictors of transmural structural alterations to the bowel wall, the disease-related...
- This $264,013 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) will support research by The Pennsylvania State University to investigate the genetic, symbiotic, and evolutionary bases of the human gut mycobiome. The central hypothesis is that genetic variants, gut bacterial genes and taxa, and/or hominid evolution shape the diversity and composition of human gut fungi. The research will involve three aims: 1) determining the human...
- This $146,922 Project Grant was awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The University of Pittsburgh is conducting research to investigate the role of gut protist-derived compounds on dietary antigen presenting dendritic cells in celiac disease. The project aims to understand how certain gut microbes can protect against virus-mediated loss of oral...
- This Project Grant award of $1,024,862.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The purpose of the award is to support the development of IMYX-3, a soluble small molecule RAB27A inhibitor, for the treatment of ulcerative colitis (UC). UC is a chronic inflammatory bowel disease affecting the colon, and...
- This federal Project Grant award, titled "PREDICTIVE MODELING OF CD-68 INFLAMMATORY AND ANTI-INFLAMMATORY CHROMATIN PACKING DOMAINS FOR PERSONALIZED BIOMARKER DISCOVERY", is provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The $188,538 grant aims to establish a framework that links transcriptomic states with chromatin structure for biomarker...
- This federal Project Grant award of $228,948 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research at Weill Medical College of Cornell University to investigate the role of the neuropeptide adrenomedullin 2 (ADM2) in regulating intestinal inflammation and promoting tissue protection in inflammatory bowel diseases (IBD) such as ulcerative...
- This federal Project Grant award of $318,554.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) will support research at Valparaiso University to investigate the regulation of chloride-driven fluid secretion and its subversion by the fungal pathogen Candida albicans. The key objectives of this 3-year research project are to: 1) determine the role of the hormone 17-β...
This Project Grant award of $191,547 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) will support research conducted by Tufts Medical Center to evaluate the role of the gut mycobiome (fungal microbiome) in ulcerative colitis. The key objectives are to: 1) assess whether persistent elevations in the fungus Candida albicans in the gut predict failure of biologic therapies in ulcerative colitis patients, 2) identify interactions between the bacterial microbiome and C. albicans that may regulate fungal growth, and 3) test the feasibility and preliminary efficacy of the antifungal medication fluconazole to alter the mycobiome and improve outcomes in ulcerative colitis. This 5-year research project aims to advance understanding of how the mycobiome contributes to inflammation and relapse in ulcerative colitis, with the goal of developing more effective microbiome-targeted treatments.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $191.5k | 9/11/25 |