The National Institute on Drug Abuse (NIDA) awarded a $445,000 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to The Children's Hospital Corporation (Boston Children's Hospital) to develop and pilot test a novel telehealth and mobile health intervention called MOMENT-V for treating cannabis use disorder in young adults. The intervention combines remote motivational enhancement therapy with ecological momentary interventions delivered via mobile app. The pilot...
The National Institute on Drug Abuse (NIDA) awarded a $1,076,018 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to Dynamicare Health Inc. in Wareham, MA. The award will fund a Phase II randomized clinical trial to evaluate the efficacy of DCH-003, a digital therapeutic that delivers contingency management for the treatment of stimulant use disorder. The trial will compare standard clinic care plus DCH-003 to standard care plus a sham digital app, with the...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will pilot an innovative digital Contingency Management (CM) treatment delivered via mobile device to Medicaid beneficiaries with co-occurring opioid and alcohol use disorders. The $390,000 award, spanning from September 2024 to August 2027, aims to: 1) identify optimal approaches to engage Medicaid beneficiaries in digital CM through Medicaid claims data...
This $668,110 Project Grant awarded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will fund the development and acceptability testing of a technology-based intervention to reduce cannabis misuse among college students. The project aims to refine an existing intervention that provides information on cannabis products, marketing, laws, and risks to increase young adults' cannabis literacy. The research will involve focus groups with...
This $591,032 Project Grant awarded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will support the development of the "COGITO" digital therapeutics platform. COGITO is intended to provide a turnkey solution for rapidly developing, evaluating, deploying, and scaling digital therapeutics to prevent, treat, or manage a wide range of health conditions with behavioral components. The funding will be used to finalize key...
This $441,000 federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will support research at Yale University to investigate the molecular changes in the brain that link cannabis use disorder and major depressive disorder. The researchers will use innovative single-cell genomics to identify transcriptomic and chromatin alterations in two key brain regions from 120 donors with cannabis use disorder, major...
This federal Project Grant award, funded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $2,415,940 to the University of Massachusetts Medical School (UMass Medical) to conduct a prospective, observational study on using digital biomarkers from wearable sensors to understand craving patterns during medications for opioid use disorder (MOUD) treatment. The key goals are to: 1) curate a high-quality dataset of craving...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to develop a novel mobile cannabis intervention for youth aged 13-17 who are using cannabis regularly. The $280,207 award to Mobile Health Interventions LLC will fund the creation of the "Adolescent CLEAR30" mobile application, which will leverage the basic framework of the existing CLEAR30 program and offer a suite of tailored tools informed...
This federal Project Grant award, ID R01DA059527, was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The $2,118,992 grant will fund a prospective investigation into the effects of cannabis use on reward and pain neurocircuits in adolescents with depression. The research aims to understand the relationships between cannabis use and depression in adolescence, which may inform prevention and intervention strategies for...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $177,110 to the Cambridge Public Health Commission (doing business as Cambridge Health Alliance) to study the impact of cannabis legalization and commercialization on substance use and mental health outcomes among individuals with psychosis. The award will fund a multi-year research project that utilizes quasi-experimental...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), is funding the development and pilot evaluation of a digital therapeutic called AMP-C. The goal of AMP-C is to address the comorbidity of cannabis use disorder (CUD) and major depressive disorder (MDD) by targeting reward dysfunction, a key shared mechanism underlying these co-occurring conditions.
The $197,640 award to the General Hospital Corporation (dba Massachusetts General Hospital) will support a pilot randomized controlled trial to evaluate the accessibility, feasibility, and preliminary efficacy of AMP-C compared to an active control group for individuals with co-occurring CUD and MDD. The project will also examine the impact of AMP-C on mechanisms of change, including passive sensing data. This research aims to provide important insights into understanding and effectively treating the comorbidity of CUD and MDD using a scalable, integrative digital therapeutic approach.