Project Grant K23AT014015
- The National Institute of Neurological Disorders and Stroke awarded Case Western Reserve University $3,778,614 on August 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop and validate transient selective neural inhibition via photobiomodulation (TSNIP) for chronic knee pain treatment. The research integrates optimized TSNIP parameters into the COSMIIC modular platform—an FDA-qualified system already proven safe for electrical stimulation and sensing in...
- The National Institute of Neurological Disorders and Stroke awarded Case Western Reserve University $109,412 on January 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to evaluate the protein homeostasis of N-methyl-D-aspartate receptors containing pathogenic GluN2B subunits. The research elucidates the proteostasis network regulating NMDA receptor folding, assembly, trafficking, and degradation, with emphasis on how...
- The National Center for Complementary and Integrative Health (NCCIH), a component of the Department of Health and Human Services National Institutes of Health, awarded $407,856 to Cleveland Clinic Lerner College of Medicine of Case Western Reserve University on August 1, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213). The recipient will conduct research examining how alpha-frequency transcranial alternating current stimulation (tACS) targeting...
- The National Institute of Neurological Disorders and Stroke awarded a cooperative agreement to Case Western Reserve University for $1,202,540 on September 1, 2026, to conduct an exploratory trial of the RESTORES (Revolutionary Electrical Stimulation Technology to Optimize Recovery of Everyone with Spinal Cord Injury) system. The recipient will customize and program open-source Networked Neuroprosthesis (NNP) components—a modular peripheral neurostimulation device designed to address multiple...
- The National Heart, Lung, and Blood Institute awarded Case Western Reserve University $760,476 on July 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop a low-field magnetic resonance imaging guided robotic catheter system for ventricular tachycardia ablation. The project addresses recurrence rates as high as 37% in ventricular tachycardia (VT) ablation procedures, particularly in patients with extensive structural or non-ischemic heart disease. The system...
- The National Institute of Biomedical Imaging and Bioengineering awarded Case Western Reserve University $218,869 under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) on August 18, 2026. The research develops and validates a novel framework for detecting freezing of gait (FOG), a sudden inability to walk affecting people with advanced Parkinson's disease and a primary cause of PD-related falls in older adults. Aim 1 uses generative...
- The National Institute on Aging awarded Case Western Reserve University $655,673 on August 15, 2026, under the Aging Research program (CFDA 93.866) to investigate the therapeutic potential of semaglutide and tirzepatide in Alzheimer's disease across animal models and real-world clinical data through May 31, 2029. The project addresses critical gaps in AD treatment by examining whether semaglutide improves clinical outcomes in real-world patients with later-stage disease, whether tirzepatide...
- Federal Project Grant Award Summary Case Western Reserve University received a $453,033 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective August 1, 2025, through July 31, 2027. The award supports research into microglial-mediated glycosaminoglycan (GAG) catabolism in mucopolysaccharidosis VII (MPS VII) neuropathology, a lysosomal storage...
- The National Institute of Neurological Disorders and Stroke awarded The Ohio State University $791,792 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop and adapt a wearable electromyography-triggered functional electronic stimulation (EMG-FES) system for stroke rehabilitation. The funded work focuses on engineering the NeuroLife Sleeve, a research-grade prototype sleeve embedded with 150 dual...
- The Centers for Disease Control and Prevention awarded a $499,995 Cooperative Agreement to Case Western Reserve University on September 30, 2026, under the CDC Investigations and Technical Assistance program (CFDA 93.283) to conduct research on the incidence and risk factors of childhood epilepsy in the United States. Case Western Reserve University's Office of Research Administration, operating in affiliation with University Hospitals of Cleveland, will conduct the research at its Cleveland,...
The National Institute of Neurological Disorders and Stroke (NINDS), part of the Department of Health and Human Services National Institutes of Health, awarded Case Western Reserve University $189,000 on July 20, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279). Case Western Reserve University, through its Office of Research Administration in affiliation with University Hospitals of Cleveland, will conduct a randomized, sham-controlled, parallel-group feasibility trial evaluating the safety, usability, adherence, retention, and data completeness of AutoSTEA—a novel needleless transcutaneous electrical acustimulation device that automatically synchronizes treatment with the user's natural breathing. The trial targets adults with epigastric pain syndrome, a subtype of functional dyspepsia affecting up to 4.5% of the U.S. population. The study will generate feasibility benchmarks and preliminary clinical and mechanistic estimates through symptom assessments and noninvasive physiologic measures including electrogastrography and electrocardiography with heart rate variability analysis. The trial is not powered to establish efficacy; pilot data will form the foundation for a future adequately powered R01 clinical trial assessing AutoSTEA's efficacy in a larger, diverse population. Work is performed in Cleveland, Ohio. The period of performance runs from July 20, 2026, through June 30, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $189.0k | 7/22/26 |