Project Grant K23AR084615
- This $159,594 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research to identify new therapeutic targets for osteogenesis imperfecta (OI), a rare genetic bone disorder. The award recipient, the Research Foundation of the City University of New York (RFCUNY), will investigate the intracellular signaling and extracellular matrix mechanisms...
- This $219,609 project grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) is aimed at developing a method to assess mechanical failure of bone matrix using in vitro cell culture. The primary goal is to overcome the current challenge of requiring whole mouse bone specimens to detect changes in bone matrix mechanical properties, by using micropillars generated from...
- This $177,000 federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research (CFDA 93.846) program, supports research to investigate genetic determinants of chondrocyte maturation and its impact on skeletal growth disorders. The research at Boston Children's Hospital, a premier pediatric medical research institution, leverages a high-throughput screening approach to identify novel...
- This federal Project Grant award of $685,866.00 was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846). The goal of this 5-year project is to leverage context-specific expression quantitative trait loci (eQTLs) to identify potential causal genes underlying genome-wide association study (GWAS) findings related to bone mineral density (BMD) and...
- This $667,125 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846), aims to develop a long-lasting, bone-targeted gene therapy for Osteogenesis Imperfecta (OI), the most common bone fragility disease. The University of Massachusetts Medical School (UMMS) will use a novel recombinant adeno-associated virus (rAAV) vector with bone-specific...
- This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to identify myeloid progenitors that maintain cortical bone mass with age and characterize factors that promote coupling within cortical bone. The $375,100 award, active from Sep 20, 2024 to Aug 31, 2026, supports research at the University of Minnesota to address the significant impact of...
- This Project Grant award, funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to refine a computational surgical decision tool for vertebral body tethering (VBT) to treat spinal deformities in children. The $616,238 award, running from September 2025 through June 2030, will incorporate findings from a large animal model to determine how skeletal maturity and...
- This $174,302 Project Grant awarded by the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) aims to characterize how adults with the childhood-onset genetic disease cystic fibrosis conceptualize their futures and plan their lives amid evolving prognoses and therapeutic innovations. The 5-year grant, awarded to the Trustees of the University of Pennsylvania, will use a disability studies framework to conduct qualitative interviews with adults with cystic fibrosis...
- This federal Project Grant award of $1,948,116.00 was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The award supports research into post-transcriptional regulation of gene expression during bone regeneration, with a focus on understanding the expression patterns and biological functions of the protein Proteoglycan 4 (PRG4) during fracture healing. The research...
- This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research Program (CFDA 93.846), supports research to mechanistically characterize how human long non-coding RNAs (lncRNAs) control chromatin organization and mediate competency for gene expression to initiate and sustain osteogenesis. The $623,628 award to the University of Vermont & State Agricultural College will fund a...
This $176,040 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to support research that will identify genetic modifiers and imaging biomarkers to predict vertebral fracture risk in individuals with cystic fibrosis. The primary objectives are to: 1) discover genetic modifiers of cystic fibrosis-related osteoporosis, 2) examine the relationship between volumetric bone density measured by CT imaging and vertebral fractures in this population, and 3) explore the association between genetic modifiers, volumetric bone density, and vertebral fracture risk. This 5-year project, awarded to The Johns Hopkins University, will generate data to enable identification of cystic fibrosis patients at highest risk of vertebral fractures, providing preliminary findings for future research grant applications. The award supports the training of a pediatric endocrinologist dedicated to an academic career in cystic fibrosis-related osteoporosis research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $176.0k | 7/31/25 |