This Project Grant award of $1,469,862 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under CFDA Program 93.846 Arthritis, Musculoskeletal and Skin Diseases Research, will fund research to investigate the cellular and molecular mechanisms by which exercise controls bone quality. The primary awardee, The Regents of the University of California, San Francisco (UCSF), will lead this 5-year project focused on uncovering the role of osteocytes and...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $166,488 to the University of California, Davis to conduct research on the role of the hypoxia-inducible factor-2a (HIF-2a) signaling pathway in driving osteocyte senescence and age-related osteoporosis. The project aims to elucidate how HIF-2a expression increases with age in osteocytes and contributes to cellular senescence, ultimately leading to bone deterioration and loss of bone strength....
This Project Grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), provides $688,634.00 in funding to The Hospital For Special Surgery Fund, Inc. (dba HSS Foundation) from December 1, 2024 to November 30, 2029. The award supports research to investigate the mechanisms by which the constitutive type-I interferon (IFN-I) response suppresses osteoblastogenesis and bone formation, especially in the context of inflammatory conditions like rheumatoid...
The Regents of the University of Minnesota was awarded a $354,222 Project Grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The grant will support research to investigate how the dystrophin-associated protein complex (DAPC) senses and adapts to biochemical, mechanical, and topographic cues in the cell microenvironment, and how this regulates myotube orientation and...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $456,808 to the Buck Institute for Research on Aging to develop innovative mass spectrometry imaging (MSI) technologies and perform deep proteomic profiling of bone tissues. The goal is to spatially visualize changes in the extracellular matrix and glycans related to osteoarthritis,...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will support research to investigate the mechanisms by which mechanical and hormonal signals interact within bone cells to stimulate bone formation. The $175,948 award, effective June 1, 2025 through May 31, 2030, will be conducted by The General Hospital Corporation, doing business as Massachusetts...
The University of Vermont & State Agricultural College was awarded a $623,628 Project Grant by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846). The grant supports scientific research to mechanistically characterize how human long non-coding RNAs (lncRNAs) control chromatin organization and mediate competency for gene expression to initiate and sustain human...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $1,938,605 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to the Van Andel Research Institute (VAI) to investigate the mechanisms by which the X-linked chromatin modifying enzyme KDM5C regulates female bone mass. The goal is to determine how KDM5C transcriptionally programs genes that control osteoclast differentiation and function, and to assess whether KDM5C...
This Project Grant award from the National Institute on Aging (NIA) under CFDA 93.866, Aging Research, aims to investigate how epigenetic deregulation of osteoblasts (bone cells) promotes age-related clonality in hematopoietic cells. The $1,335,986 award to The Trustees of Columbia University in the City of New York, with a performance period from Aug 2024 to Apr 2029, will support research to: Delineate how epigenetically modified mouse and human stromal cells and osteoblasts promote the...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) provides $279,354 to Northwestern University to conduct research on preventing bone loss and maintaining bone mass after spinal cord injury. The study will evaluate the use of the drug denosumab followed by zoledronic acid to prevent significant bone loss that commonly occurs in individuals with...