Project Grant K23AI201637
- The National Institute of Allergy and Infectious Diseases awarded Northwestern University $480,000 on August 13, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to identify the phenotypic, genetic, and epigenetic traits that predispose certain Salmonella serovars to chronic infection. The project addresses the clinical challenge that non-typhoidal Salmonella causes persistent infections resistant to host immunity and antibiotic therapy, yet the mechanisms driving...
- The National Institute of Allergy and Infectious Diseases awarded Northwestern University $549,246 on August 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to fund Project Grant R01AI192692, which investigates substrate selectivity and regulation of YHAM, a 3'-5' exonuclease in Methicillin-resistant Staphylococcus aureus (MRSA). The research examines how YHAM, an understudied bacterial enzyme required for MRSA virulence, functions through an unusual...
- The National Institute of Allergy and Infectious Diseases awarded a $1.478 million cooperative agreement to Northwestern University on July 10, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct a Phase 2 pragmatic, stratified, randomized, double-blind, multi-center clinical trial comparing tobramycin/beta-lactam combination antibiotic therapy to beta-lactam monotherapy for treating Pseudomonas aeruginosa ventilator-associated pneumonia. The trial will...
- The National Institute of Allergy and Infectious Diseases awarded Northwestern University $334,649 on July 20, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate fetal adaptive immune responsiveness in preterm premature rupture of membranes. The research measures whether the fetal adaptive immune system, traditionally considered inert or tolerogenic, mounts a response to ascending bacterial infection following membrane rupture. The project focuses on...
- The National Institute of Allergy and Infectious Diseases awarded Northwestern University $154,394 on June 18, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop a novel technology for studying T cell differentiation in vivo using CRISPR-based genetic screens combined with single-cell sequencing. The research addresses limitations of existing single-cell CRISPR-sequencing methods, which have been performed primarily in vitro using immortalized cell lines...
- The National Institute of Allergy and Infectious Diseases awarded Northwestern University $480,000 on August 3, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the molecular mechanisms underlying anti-aquaporin-4 responses in neuromyelitis optica spectrum disorder (NMOSD). The research addresses the autoimmune pathogenesis of NMOSD, a severe central nervous system disease driven by T cell and autoantibody responses against aquaporin-4 on...
- The National Institute of Allergy and Infectious Diseases awarded Northwestern University a $1,279,395 cooperative agreement on August 1, 2026, to investigate fundamental mechanisms governing the induction of antigen-specific IgA in the gastrointestinal tract under the Allergy and Infectious Diseases Research program (CFDA 93.855). The research project examines two distinct pathways generating affinity-matured gut IgA following oral immunization with protein antigens. The first pathway,...
- The National Institute of Allergy and Infectious Diseases awarded Northwestern University $440,000 on February 5, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate neutrophil priming as a method of macrophage functional training to modulate inflammatory responses in autoimmune diseases such as rheumatoid arthritis. The research explores how neutrophils can instruct macrophage activity and establish innate immune memory, with the goal of developing...
- The National Institute of Allergy and Infectious Diseases awarded Northwestern University $431,784 on February 19, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on Pseudomonas aeruginosa carriage in the gastrointestinal tract. The funded research investigates how hospitalized patients acquire P. aeruginosa colonization in the GI tract, which serves as a major reservoir for subsequent spread to other body sites and infection. The recipient will...
- The National Institute of Allergy and Infectious Diseases awarded The Johns Hopkins University $195,640 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research integrating genomic and clinical approaches to define and prevent cefiderocol resistance in carbapenem-resistant organisms. The research addresses gaps in understanding cefiderocol resistance mechanisms and clinical use in carbapenem-resistant organisms, which cause severe...
The National Institute of Allergy and Infectious Diseases awarded Northwestern University $159,140 on August 19, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct molecular epidemiology research on New Delhi metallo-B-lactamase-producing Enterobacterales (NDM-E) infections. The research integrates genotype, phenotype, and patient-level outcomes to develop allele-specific therapeutic guidance for NDM-E treatment. Aim 1 defines the genetic epidemiology of NDM-E and links allelic diversity to susceptibility of cefiderocol, aztreonam-avibactam, and late-stage investigational agents cefepime-taniborbactam, cefepime-zidebactam, and cefepime-nacubactam, generating an NDM-allele antibiogram to guide therapy. Aim 2 identifies resistance mechanisms to NDM-directed antibiotics through comparative genomics of resistant organisms and susceptible reference isolates. Aim 3 compares clinical outcomes of cefiderocol- versus aztreonam-avibactam-treated patients with NDM-E infections, evaluating 30-day mortality and 90-day resistance emergence using propensity score methodology. Approximately 800 isolates from Northwestern University, Johns Hopkins University, and the University of Pennsylvania undergo broth microdilution, short- and long-read sequencing, and bioinformatic analysis, with patient data linked to allele-specific resistance correlates. Career development is central to the award, with structured training in whole-genome sequencing, bioinformatics, and high-dimensional statistical methods. Place of performance is Chicago, Illinois. The period of performance runs from August 19, 2026, through July 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $159.1k | 8/19/26 |