Project Grant R01AI196475
- The National Institute of Allergy and Infectious Diseases awarded Northwestern University $240,000 on May 8, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate LAG3-dependent regulation of microglial functions in autoimmune neuroinflammation. The research uses microglia-specific LAG3-mutant mouse models to test whether the inhibitory co-receptor LAG3 regulates microglial activation and function in experimental autoimmune encephalomyelitis and related...
- The National Institute of Allergy and Infectious Diseases awarded Northwestern University a $1,279,395 cooperative agreement on August 1, 2026, to investigate fundamental mechanisms governing the induction of antigen-specific IgA in the gastrointestinal tract under the Allergy and Infectious Diseases Research program (CFDA 93.855). The research project examines two distinct pathways generating affinity-matured gut IgA following oral immunization with protein antigens. The first pathway,...
- The National Institute of Allergy and Infectious Diseases awarded Northwestern University $725,778 on August 19, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate alphaherpesvirus axonal transport and neuroinvasion mechanisms. The research deciphers how neuroinvasive herpesviruses such as herpes simplex virus type 1 and pseudorabies virus invade the nervous system to establish lifelong latent infections; identifies intrinsic barriers to neural...
- The National Institute of Allergy and Infectious Diseases awarded Northwestern University $334,649 on July 20, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate fetal adaptive immune responsiveness in preterm premature rupture of membranes. The research measures whether the fetal adaptive immune system, traditionally considered inert or tolerogenic, mounts a response to ascending bacterial infection following membrane rupture. The project focuses on...
- The National Institute of Allergy and Infectious Diseases awarded Northwestern University $440,000 on February 5, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate neutrophil priming as a method of macrophage functional training to modulate inflammatory responses in autoimmune diseases such as rheumatoid arthritis. The research explores how neutrophils can instruct macrophage activity and establish innate immune memory, with the goal of developing...
- The National Institute of Allergy and Infectious Diseases awarded Northwestern University $493,889 on April 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate mechanisms of food-specific antibody induction in the gut. The research will elucidate how invariant natural killer T cells, type 2 conventional dendritic cells, and T follicular helper cells work in concert to promote production of food-specific immunoglobulin E antibodies, using a mouse model...
- The National Institute of Allergy and Infectious Diseases awarded the University of Illinois $790,913 on July 13, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to define the molecular and cellular mechanisms by which gut commensal microbiota-specific T cells drive intestinal and neuroinflammation. The project investigates how segmented filamentous bacteria (SFB)-specific CD4 T cells, initially generated in gut-draining mesenteric lymph nodes and intestines in...
- The National Institute of Allergy and Infectious Diseases awarded The University of Chicago $1,177,657 on July 10, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the biophysical and structural basis of T cell selection at the intersection of conventional and regulatory T cell repertoires. The research addresses autoimmune disease pathogenesis by examining how CD4+ T cells recognize peptide antigens complexed with MHC class II molecules through the T...
- The National Institute of Allergy and Infectious Diseases awarded Northwestern University $159,140 on August 19, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct molecular epidemiology research on New Delhi metallo-B-lactamase-producing Enterobacterales (NDM-E) infections. The research integrates genotype, phenotype, and patient-level outcomes to develop allele-specific therapeutic guidance for NDM-E treatment. Aim 1 defines the genetic epidemiology of...
- The National Institute of Allergy and Infectious Diseases awarded Northwestern University $440,000 on February 10, 2026, for research engineering supramolecular peptide amphiphile nanofibers displaying fibroblast growth factor-2 mimetic signals to protect endothelial cell barriers and prevent allograft vasculopathy in solid organ transplantation. The award is a Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855). The research addresses long-term graft loss from...
The National Institute of Allergy and Infectious Diseases awarded Northwestern University $480,000 on August 3, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the molecular mechanisms underlying anti-aquaporin-4 responses in neuromyelitis optica spectrum disorder (NMOSD). The research addresses the autoimmune pathogenesis of NMOSD, a severe central nervous system disease driven by T cell and autoantibody responses against aquaporin-4 on astrocytes. The project will elucidate the role of type-II interferon signaling and the JAK/STAT-1 pathway in anti-AQP4 autoimmunity using an active immunization animal model based on the pathogenic AQP4201-220 peptide. The work targets gaps in understanding how NMOSD pathogenic mechanisms differ from other autoimmune central nervous system diseases and seeks to guide development of new therapeutics beyond current treatments (high-dose corticosteroids, plasmapheresis, and disease-modifying therapies targeting B cells, complement, or IL-6 signaling), which carry significant side effects, high costs, and limited durable disease control. Work is performed in Chicago, Illinois. The period of performance runs from August 3, 2026, through July 31, 2031. The award is classified as a Project Grant, the standard assistance type for individual research projects under the National Institute of Allergy and Infectious Diseases research portfolio.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $480.0k | 7/31/26 |