Project Grant R01AI192692
- The National Institute of Allergy and Infectious Diseases awarded Northwestern University $159,140 on August 19, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct molecular epidemiology research on New Delhi metallo-B-lactamase-producing Enterobacterales (NDM-E) infections. The research integrates genotype, phenotype, and patient-level outcomes to develop allele-specific therapeutic guidance for NDM-E treatment. Aim 1 defines the genetic epidemiology of...
- The National Institute of Allergy and Infectious Diseases awarded Northwestern University $440,000 on February 5, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate neutrophil priming as a method of macrophage functional training to modulate inflammatory responses in autoimmune diseases such as rheumatoid arthritis. The research explores how neutrophils can instruct macrophage activity and establish innate immune memory, with the goal of developing...
- The National Institute of Allergy and Infectious Diseases awarded the University of Illinois $236,407 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the structural basis of ARMA-mediated resistance to aminoglycoside antibiotics targeting the bacterial ribosome. The research addresses how ARMA methyltransferases confer high-level resistance to aminoglycosides—a cornerstone class of ribosome-binding antibacterial drugs used...
- The National Institute of Allergy and Infectious Diseases awarded $440,908 to the University of Illinois on February 5, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop extracellular vesicle-inspired nano vesicles for CRISPR-based targeting of methicillin-resistant Staphylococcus aureus (MRSA). The project addresses antibiotic resistance in MRSA strains, the leading cause of healthcare-associated infections in the United States and globally. Current...
- The National Institute of Allergy and Infectious Diseases awarded President and Fellows of Harvard College $253,500 on May 21, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate how a novel uridyltransferase enzyme named NAGU coordinates peptidoglycan cell wall synthesis with turgor pressure regulation in Staphylococcus aureus. Research will combine genetics, biochemistry, cell biology, and metabolomics to characterize NAGU's cellular roles and...
- The National Institute of Allergy and Infectious Diseases awarded Northwestern University a $1,279,395 cooperative agreement on August 1, 2026, to investigate fundamental mechanisms governing the induction of antigen-specific IgA in the gastrointestinal tract under the Allergy and Infectious Diseases Research program (CFDA 93.855). The research project examines two distinct pathways generating affinity-matured gut IgA following oral immunization with protein antigens. The first pathway,...
- The National Institute of Allergy and Infectious Diseases awarded Northwestern University $431,784 on February 19, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on Pseudomonas aeruginosa carriage in the gastrointestinal tract. The funded research investigates how hospitalized patients acquire P. aeruginosa colonization in the GI tract, which serves as a major reservoir for subsequent spread to other body sites and infection. The recipient will...
- The National Institute of Allergy and Infectious Diseases awarded Northwestern University $480,000 on August 3, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the molecular mechanisms underlying anti-aquaporin-4 responses in neuromyelitis optica spectrum disorder (NMOSD). The research addresses the autoimmune pathogenesis of NMOSD, a severe central nervous system disease driven by T cell and autoantibody responses against aquaporin-4 on...
- The National Institute of Allergy and Infectious Diseases awarded Northwestern University $151,040 on March 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the mechanisms controlling Neisseria gonorrhoeae type IV pilus dynamics. The research uses genetic, biochemical, and biophysical techniques to define how the TFPC protein contributes to type IV pilus dynamics and architecture in the gonococcus. The project characterizes the previously...
- The National Institute of Allergy and Infectious Diseases awarded the University of Illinois $736,822 on February 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate how bacterial lipases drive host immunity and physiology during infection. The research focuses on Staphylococcus aureus lipases, particularly the secreted lipase GEH, which the recipient's laboratory has shown inhibits activation of innate immune cells and blunts pro-inflammatory...
The National Institute of Allergy and Infectious Diseases awarded Northwestern University $549,246 on August 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to fund Project Grant R01AI192692, which investigates substrate selectivity and regulation of YHAM, a 3'-5' exonuclease in Methicillin-resistant Staphylococcus aureus (MRSA). The research examines how YHAM, an understudied bacterial enzyme required for MRSA virulence, functions through an unusual heterohexameric assembly composed of full-length and truncated protein isoforms derived from intragenic translation. The work comprises three aims: comparing the biochemical and structural properties of the two YHAM isoforms and identifying their native RNA substrates globally; assessing the functional significance of the short YHAM isoform at the cellular level; and investigating how cells regulate the stoichiometry of the two isoforms. The project explores a bacterial "genes-within-genes" mechanism and may yield insights applicable to biotechnology and therapeutic development targeting this atypical RNase. Work is performed in Chicago, Illinois. The project runs through July 31, 2031. Northwestern University's Sponsored Research Division administers the award as a Project Grant, the standard assistance type for NIH research grants to individual principal investigators and research teams.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $549.2k | 7/30/26 |