Project Grant R21AG095658
- Federal Project Grant Award Summary The University of Pennsylvania received a $427,919 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded August 15, 2025, with completion targeted for July 31, 2027. This award supports the development of integrated micro-to-macro network models designed to advance understanding of disease spread mechanisms in Frontotemporal Dementia (FTD). The research aims to distinguish between the two primary pathologies...
- Federal Grant Award Summary The University of Pittsburgh received a $664,619 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) awarded January 1, 2026, with completion by December 31, 2030. This grant funds comprehensive research into multiscale neurometabolic coupling across age-specific populations, with particular focus on late-onset Alzheimer's disease models. The research delivers three primary products: (1) single-cell neurometabolic coupling...
- Federal Grant Award Summary The National Institute on Aging awarded University of Maryland, Baltimore a $589,154 Project Grant under the Aging Research program (CFDA 93.866) effective February 1, 2026, through January 31, 2031. This research project develops and validates a normalized cerebrovascular reactivity (NCVR) magnetic resonance imaging technique to improve detection of vascular contributions to cognitive impairment in small-vessel disease patients. The project addresses a critical gap...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded J. David Gladstone Institutes a Project Grant totaling $801,193 on February 15, 2026, under the Aging Research program (CFDA 93.866) to investigate how the APOE4 allele disrupts brain energy metabolism in Alzheimer's disease. The research will employ innovative assays and imaging techniques to measure metabolic shifts from aerobic respiration to glycolysis and characterize the production of toxic metabolites in both...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded the University of Pennsylvania $148,050 under the Aging Research program (CFDA 93.866) on October 29, 2025, for an Individual National Research Service Award (NRSA) with a completion date of May 31, 2027. This award provides research training and mentorship to enable the applicant, an experienced acute care nurse and clinical nurse specialist, to develop competencies as an independent researcher focused on...
- Federal Project Grant Award Summary The Johns Hopkins University received a $618,410 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded February 1, 2026, with a completion date of January 31, 2029. The award supports the development of a deep learning-based miniature microscope designed to advance early detection and understanding of Alzheimer's disease (AD) pathogenesis through high-resolution brain imaging in preclinical models. The...
- Federal Grant Award Summary The University of Pennsylvania received a $446,875 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded January 15, 2026, with completion targeted for December 31, 2028. This research project investigates how specific genetic variants and aging jointly influence polyunsaturated fatty acid (PUFA) metabolism and eicosanoid production in white adipose tissue (WAT). The project leverages human-derived induced...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded the University of Pennsylvania $243,000 under the Aging Research program (CFDA 93.866) on September 5, 2025, with a completion date of May 31, 2030. This project grant supports research investigating the impact of frailty on disease relapse and therapy intensity in older adults with acute myeloid leukemia (AML), with particular focus on identifying biomarkers and optimizing treatment selection. The research...
- Federal Grant Award Summary The University of Pennsylvania received a $613,823 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) effective September 1, 2025, through August 31, 2030, to conduct a randomized clinical trial assessing the effectiveness of the SENSE4SAFETY intervention in reducing fall risk among community-dwelling older adults with mild cognitive impairment (MCI). The project delivers a technology-supported intervention system that combines...
- Summary of Federal Project Grant Award The National Institute on Aging (part of the National Institutes of Health) awarded a $3.52 million Project Grant under the Aging Research program (CFDA 93.866) to the University of California, Davis on March 15, 2026, with completion targeted for November 30, 2030. This award funds the continuation of "Longitudinal MRI Measures of Cerebrovascular Injury and Alzheimer's Disease Atrophy in a Study of Latinos" (SOL-INCA-MRI LONG), a longitudinal...
The University of Pennsylvania received a $429,498 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded April 15, 2026, with a completion date of March 31, 2028. The grant supports the development of a three-dimensional Magnetic Resonance Imaging (MRI) method for cerebral metabolic rate of oxygen (CMRO2) mapping in dementia patients. The research addresses a significant gap in non-invasive brain imaging technology by advancing MRI-based approaches to measure oxygen metabolism in the brain, offering an alternative to the current gold-standard Positron Emission Tomography (PET) imaging with oxygen-15 tracers, which is complex, costly, and limited in availability. This research is directly relevant to understanding energy metabolism disruption in Alzheimer's disease and related dementias, potentially enabling quantitative validation of ketogenic dietary interventions and advancing diagnostic capabilities for neurodegenerative diseases. The project contributes to the National Institute on Aging's mission to support biomedical research directed toward understanding aging processes and age-related diseases, with particular emphasis on Alzheimer's disease mechanisms and treatment approaches. The deliverable will be an improved neuroimaging methodology capable of both global and regional brain oxygen metabolism assessment, facilitating better characterization of age and neurodegeneration-related changes in brain energy metabolism that correlate more effectively with cognitive decline than existing biomarkers.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $429.5k | 4/7/26 |