Project Grant K23AG090624
- This Project Grant award of $673,012 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to understand the neuromechanical bases for the increased energy cost of walking in aging. The University of Massachusetts is the primary awardee, with the goal of determining how age-related changes in gait strategy combine with muscle weaknesses to increase the energy cost of walking in older adults. The research will address key knowledge gaps regarding relative...
- This Project Grant award from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), aims to identify multi-scale mechanisms contributing to age-related increases in the metabolic cost of walking and decreases in walking speed. The $3,224,215 award to Georgia Tech Research Corp, to be completed by July 31, 2029, will leverage a multi-scale, computational-experimental approach to probe the cellular-to-behavioral mechanisms linking the...
- This Project Grant award, valued at $1,311,772.00, was provided by the Department of Health and Human Services National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310). The award, granted to the Regents of the University of Minnesota on September 30, 2025, supports research into the mechanisms of neuroplasticity and cerebral blood flow that enable "fast-moving superagers" to maintain exceptional physical and cognitive function into advanced age....
- This Project Grant award from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), will provide $128,321 to the Regents of the University of Michigan to conduct research on retrosplenial cortex circuits in preclinical models of Alzheimer's disease. The project aims to systematically dissect the retrosplenial cortex circuitry, with a focus on understanding how a specific cell type called "low-rheobase" cells and their inputs from the...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $705,385 to Northeastern University to conduct a large-scale study investigating mediators and moderators of executive function training in older adults. The study aims to improve the rigor and reproducibility of research on cognitive plasticity in older adults, many of whom are at risk for Alzheimer's disease and related dementias. The study will collect data from 1,250 older adults aged 60+ to...
- This federal Project Grant award of $203,278.00, provided by the National Institute on Aging under the Aging Research program (CFDA 93.866), will fund research to understand the behavioral and neurobiological mechanisms underlying age-related shifts in motivation and their impact on daily life activity participation in older adults. The research will employ a multilevel, multimodal approach, utilizing behavioral, psychophysiological, neuroimaging, and naturalistic assessment methods to...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $234,000.00 to the Regents of the University of Michigan for a project titled "LONG-LIVED ACTIVATION OF PARENCHYMAL BORDER MACROPHAGES USING IMMUNOCYTOKINES TO ADDRESS AGING- AND ALZHEIMER'S DISEASE-ASSOCIATED DEFICITS IN CEREBROSPINAL FLUID DYNAMICS". The project aims to develop immunocytokines - monoclonal or bispecific antibodies fused to macrophage colony-stimulating factor...
- The National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), awarded a $650,872 Project Grant to The Johns Hopkins University to investigate the bioenergetic, physiological, and gait mechanics mechanisms that contribute to the high energetic cost of walking in older adults. The 5-year project, which began on August 15, 2025, will use clinical, laboratory, and sensor-based assessments to detect changes in health and mobility consistent with the onset and...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) will support a $185,074 research study conducted by the University of California, Berkeley. The goal of the study is to examine how brain network connectivity is associated with Alzheimer's disease (AD) risk, longitudinal pathology accumulation, and aging. The researchers will use positron emission tomography (PET) imaging and resting-state functional MRI (rs-fMRI) to investigate the mechanisms of how...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $156,000.00 to the Regents of the University of Michigan, to be completed by April 30, 2027. The project aims to evaluate a mild behavioral impairment (MBI) diagnostic framework and map structural brain network changes associated with MBI in early-stage Alzheimer's disease and related dementias (ADRD). Specifically, the project will define network-level structural alterations linked to MBI in...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) is funding a study to investigate the relationships between measures of central nervous system function and walking performance in older, taxane-treated female breast cancer survivors. The $189,486 award to the Regents of the University of Michigan will be used to: 1) compare executive function's role in dual-task gait performance between the target population and cancer-free controls; 2) assess prefrontal cortex activation during dual-task walking; and 3) evaluate the acute effects of transcranial direct current stimulation on gait performance in the target population. The research aims to provide proof-of-concept that central nervous system dysfunction, in addition to peripheral neuropathy, contributes to mobility disability in this vulnerable population, and identify a novel rehabilitation target. The project will run from September 1, 2025 through June 30, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $189.5k | 8/28/25 |