Project Grant DP2AG101104
- The Regents of the University of Minnesota will receive $4.67 million under a three-year Project Grant from the National Institute on Aging within the Department of Health and Human Services. The grant funds research under the Aging Research program (CFDA 93.866) to characterize neuroplastic changes and their relationship to emerging motor and cognitive deficits in individuals with isolated rapid eye movement sleep behavior disorder (IRBD). Over the period of performance from August 2022 through...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $705,385 to Northeastern University to conduct a large-scale study investigating mediators and moderators of executive function training in older adults. The study aims to improve the rigor and reproducibility of research on cognitive plasticity in older adults, many of whom are at risk for Alzheimer's disease and related dementias. The study will collect data from 1,250 older adults aged 60+ to...
- This federal Project Grant award of $2,358,537.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a research project titled "Epigenetic Aging, Cognitive Function and Exercise in Older Adults" at the University of Pittsburgh. The project aims to investigate the impact of exercise on epigenetic aging and its relationship to cognitive function, brain health, and Alzheimer's disease biomarkers in non-cognitively impaired older adults. The award period runs from...
- This Project Grant award of $343,350, provided by the National Institute on Aging (NIA, CFDA 93.866 Aging Research), supports research to investigate the neurocomputational mechanisms underlying age-related deficits in visual perception. The project aims to examine the role of alpha-gamma neural oscillations in deteriorating contrast sensitivity and 3D structure-from-motion perception, which significantly impact the health and quality of life of aging adults. Employing functional and...
- This federal Project Grant award of $423,500 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research into the behavioral, electrophysiological, and pupil-based rhythms of attention and memory in young and older adults. The project will examine attention and memory performance concurrently with electroencephalography (EEG) and pupillometry, with a sample of 75 young and 75 cognitively unimpaired older adults screened for Alzheimer's disease pathology. The goal is...
- This $1,554,682 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund the development of three new multi-modal atlases based on high-resolution Human Connectome Project (HCP) data. The objectives are to: 1) Create a new data-driven atlas of spatially overlapping weighted grey-matter functional networks, 2) Develop a new atlas of white matter tracts and their corresponding grey matter projection territories, and 3) Complete a semi-automated...
- This federal Project Grant award of $203,278.00, provided by the National Institute on Aging under the Aging Research program (CFDA 93.866), will fund research to understand the behavioral and neurobiological mechanisms underlying age-related shifts in motivation and their impact on daily life activity participation in older adults. The research will employ a multilevel, multimodal approach, utilizing behavioral, psychophysiological, neuroimaging, and naturalistic assessment methods to...
- This Project Grant award of $437,875 from the National Institute on Aging's Aging Research program (CFDA 93.866) will fund a 2-year research project at the University of California, San Diego to quantify neurovascular protein lifetimes in the central nervous system under healthy, aging, and Alzheimer's disease conditions. The key objectives are to generate a comprehensive atlas of neurovascular protein lifetimes and identify changes associated with aging and Alzheimer's disease. The project will...
- This federal Project Grant award of $698,032 from the National Institutes of Health (NIH) National Institute on Aging (CFDA 93.866 Aging Research) is focused on testing the mechanisms that link high-level cognition and perception in normal aging. The research project, conducted by the University of Texas at San Antonio, aims to determine if attention control and effort, which decline with age, are the common mechanisms that connect perception and cognition. The study will use a multimodal...
- This Project Grant award from the National Science Foundation's (NSF) Social, Behavioral, and Economic Sciences (CFDA 47.075) program will provide $698,115 to the University of Southern California (USC) to investigate how brief social interactions can affect brain function and cognitive performance in older adults. The project will use advanced brain imaging techniques, such as functional MRI, to study how these interactions influence the brain's salience network and its connections to other...
This Project Grant award, valued at $1,311,772.00, was provided by the Department of Health and Human Services National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310). The award, granted to the Regents of the University of Minnesota on September 30, 2025, supports research into the mechanisms of neuroplasticity and cerebral blood flow that enable "fast-moving superagers" to maintain exceptional physical and cognitive function into advanced age. The project will use electroencephalography (EEG) and transcranial Doppler ultrasound (TCD) to study the dynamic interactions between brain neural and vascular function during physical movement in older adults aged 75 and above who exhibit exceptionally fast walking speeds and are free of cognitive decline. The goal is to test the hypothesis that these "fast-moving superagers" possess unique neuroplasticity and cerebrovascular profiles that are neuroprotective and enable their remarkably high physical and cognitive function as they approach their 9th and 10th decades. The project will run through August 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.3m | 9/15/25 |