Project Grant K22CA296487
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. a Project Grant of $1.10M under the Cancer Treatment Research program (CFDA 93.395), effective August 13, 2025, through April 30, 2030. This research project investigates the transcriptional and epigenetic mechanisms controlling CD8+ tumor-infiltrating lymphocytes (TILs), with a focus on understanding how the transcription factor BCL11B regulates critical T...
- Federal Grant Award Summary H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. received a $682,495 Project Grant award from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396), effective June 1, 2026 through May 31, 2031. This five-year research project, titled "Characterizing the SPOP-BRAF-mTORC1 Signaling Axis in Melanoma Pathogenesis," supports fundamental cancer biology research aimed at advancing understanding of melanoma...
- Federal Grant Award Summary H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. received a $157,248 Project Grant from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398) to support biomedical research training and career development in cancer research. The award, effective September 1, 2025, through August 31, 2028, funds investigator-initiated research focused on understanding the oncogenic roles of alarmins and monocytes in triple...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. a Project Grant of $433,256 under the Cancer Treatment Research program (CFDA 93.395) for the period of September 1, 2025 through August 31, 2027. This award supports exploratory research into the role of antisense ribonucleic acids (asRNAs) in melanoma development and transformation. The project will deliver scientific research and analysis focused on...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. a Project Grant of $607,249 under the Cancer Cause and Prevention Research program (CFDA 93.393) on May 1, 2026, with a completion date of April 30, 2031. The award supports a five-year research project titled "Defining the Role of MAFG in Melanocyte Transformation and Melanoma Development," which investigates the transcription factor MAFG...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. a Project Grant of $851,463 under the Cancer Cause and Prevention Research program (CFDA 93.393) for the five-year period from September 1, 2025, through August 31, 2030. The funded research project, "Harnessing Big Data to Understand the Confluence of HIV and Cancer Stigma in the US Southeast," will deliver a comprehensive investigation into how...
- Federal Project Grant Award Summary H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. received a $687,593 Project Grant award from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) on May 12, 2026, with an ultimate completion date of April 30, 2031. The research project investigates cysteine acquisition and utilization mechanisms in lung adenocarcinoma, challenging the current understanding of how tumor cells obtain cysteine. The project...
- Federal Project Grant Award Summary The National Cancer Institute awarded $433,256 under the Cancer Treatment Research program (CFDA 93.395) to H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc., for a two-year project (June 1, 2026 – May 31, 2028) focused on fragment-based drug discovery targeting epithelial-to-mesenchymal transition (EMT)-mediated resistance in EGFR (epidermal growth factor receptor)-mutant lung cancer. The research employs fragment-based chemical...
- Federal Grant Award Summary The National Cancer Institute awarded H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. a Project Grant under the Cancer Research Manpower program (CFDA 93.398) in the amount of $123,182.00, effective July 17, 2025, with a completion date of June 30, 2027. This award supports a Pathway to Independence Award (K99/R00) research project investigating the mechanisms by which dormant disseminated breast cancer cells communicate with their surrounding...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc., a Project Grant of $734,942 under the Cancer Cause and Prevention Research program (CFDA 93.393) effective August 1, 2025, through July 31, 2030. This project addresses cardiovascular disease (CVD) risk in breast cancer survivors by generating novel DNA methylation biomarker data from the Pathways Study, a prospective cohort of 4,504 women diagnosed with...
H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. received a $174,949 Project Grant from the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398) for the period July 1, 2026, through June 30, 2029. The award supports investigator-initiated research examining the tumor cell-intrinsic role of Stimulator of Interferon Genes (STING) signaling in the spontaneous and therapeutic induction of tertiary lymphoid structures (TLSs) within tumors. The research aims to elucidate mechanisms by which STING pathway activation in melanoma cells promotes the formation and maintenance of TLSs—immune-rich structures associated with improved responses to immunotherapy. The project delivers scientific research services addressing two primary objectives: (1) assessing whether baseline STING status in tumor cells influences spontaneous TLS formation using immunotherapy-naive human melanoma samples, and (2) dissecting therapeutic mechanisms underlying TLS induction following pharmacologic STING activation in murine melanoma models. Through these investigations conducted at the Tampa, Florida facility, the research is designed to generate novel insights into tumor immunogenicity and effector T-cell trafficking, thereby contributing to the National Cancer Program's strategic priorities in cancer immunotherapy and advancing the scientific understanding necessary to enhance immune checkpoint inhibitor efficacy in cancer treatment.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $174.9k | 6/8/26 |