Project Grant R01CA299434
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. a Project Grant of $433,256 under the Cancer Treatment Research program (CFDA 93.395) for the period of September 1, 2025 through August 31, 2027. This award supports exploratory research into the role of antisense ribonucleic acids (asRNAs) in melanoma development and transformation. The project will deliver scientific research and analysis focused on...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. a Project Grant totaling $549,460 under the Cancer Treatment Research program (CFDA 93.395) for the period of August 13, 2025 through April 30, 2030. This research initiative focuses on understanding the biological mechanisms controlling CD8+ tumor-infiltrating lymphocytes (TILs) and their progression from functional precursor cells to terminally exhausted...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc., a Project Grant of $734,942 under the Cancer Cause and Prevention Research program (CFDA 93.393) effective August 1, 2025, through July 31, 2030. This project addresses cardiovascular disease (CVD) risk in breast cancer survivors by generating novel DNA methylation biomarker data from the Pathways Study, a prospective cohort of 4,504 women diagnosed with...
- Federal Project Grant Award Summary H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. received a $157,248 Project Grant from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398) to support investigator-initiated cancer research and training. The award, effective from September 1, 2025, through August 31, 2028, funds research examining the oncogenic roles of alarmins and monocytes in triple negative myelofibrosis (TN-MF), a particularly...
- This $697,590 federal Project Grant award from the Defense Health Agency (CFDA 12.420 - Military Medical Research and Development program) supports research at the H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. (Moffitt Cancer Center) to evaluate B-T cell cross-talk within tertiary lymphoid structures in melanoma progression and immune checkpoint blockade. The grant, with a performance period from July 1, 2024 to June 30, 2027, aims to advance scientific understanding of...
- This Project Grant award of $1,221,625.00 from the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420) supports research by H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. to develop novel genetic mouse models for studying the progression and metastasis of uveal melanoma. The award period runs from June 1, 2024 to May 31, 2027. Moffitt Cancer Center is a prominent National Cancer Institute-designated comprehensive cancer center...
- Federal Project Grant Award Summary Boston Children's Hospital received a $679,604 Project Grant award from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396), effective August 1, 2025 through July 31, 2030. The grant supports fundamental research investigating pathways involved in melanoma initiation and formation using zebrafish genetic models. Research activities include studying melanocyte-specific expression of oncogenic mutations, identifying and...
- The Department of Defense's Military Medical Research and Development program (CFDA 12.420) awarded a $2,837,644 Project Grant to the H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. in Tampa, Florida. The funding will support "Translational Studies for Targeted Alpha-Particle Therapy for Rare Melanomas" over a 4-year period from September 1, 2023 to August 31, 2027. This project grant aims to advance research into innovative cancer therapies, specifically exploring...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded a $169,000 Project Grant under the Cancer Biology Research program (CFDA 93.396) to Icahn School of Medicine at Mount Sinai, effective August 1, 2025, through July 31, 2027. This research grant supports a two-year investigation into epigenetic regulation of melanoma-associated fibroblast plasticity, specifically examining how histone variant dysfunction affects the tumor microenvironment (TME). The principal...
- Federal Grant Award Summary The National Cancer Institute awarded The Johns Hopkins University a $510,431 Project Grant under the Cancer Biology Research program (CFDA 93.396) effective July 1, 2025 through June 30, 2030. This award supports fundamental research investigating the mechanisms of metastatic recurrence and therapeutic resistance in melanoma, with particular emphasis on understanding how aging influences tumor dormancy and the microenvironment. The research examines Wnt signaling...
The National Cancer Institute (NCI) awarded H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. a Project Grant totaling $607,249 (awarded May 1, 2026; completion April 30, 2031) under the Cancer Cause and Prevention Research program (CFDA 93.393). This research project is designed to define the role of MAFG (a transcription factor) in melanocyte transformation and melanoma development. The research will deliver scientific findings and mechanistic insights into how MAFG functions as both a driver of melanoma initiation and progression and as a potential therapeutic vulnerability in this disease. The grant supports two primary research objectives: (1) establishing MAFG's foundational impact in melanoma development through comprehensive evaluation of its role in melanocyte transformation, melanoma initiation, malignant progression, and metastasis across various genetic contexts using an ESC-GEMM (embryonic stem cell-genetically engineered mouse model) platform; and (2) deciphering MAFG's oncogenic mechanisms through investigation of its binding partners, particularly its cooperation with MITF (a lineage transcription factor) in driving melanomagenesis. The research outcomes are intended to inform future therapeutic intervention strategies targeting MAFG in melanoma treatment.Federal Project Grant Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $607.2k | 4/6/26 |