Project Grant K22AI182327
Award Date
5/15/25
Completion Date
4/30/27
Dollars Obligated
$158K
Federal Agency
National Institute of Allergy and Infectious Diseases
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Clemson, SC 29634, USA
Similar Awards
The University of Georgia Research Foundation, Inc. (UGA Research Foundation) was awarded a $443,944 federal Project Grant by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant will fund a 5-year research project to explore the genetic basis of two key pathogenesis traits in the Cryptococcus genus of fungal pathogens - adaptation to high temperatures and resistance to azole antifungal drugs. The...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to investigate the host-pathogen dynamics between the pathogen Cryptococcus neoformans (CN) and HIV in microglia cells. The $232,073 award, active from November 2024 to October 2026, aims to explore the impact of CN replicative aging on its survival and growth in the central nervous system of AIDS patients....
This $494,696 federal Project Grant award, made by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to advance understanding of the translational control mechanisms that regulate the ability of the fungal pathogen Candida albicans to respond to host environmental stresses and undergo morphological transitions critical for virulence. The research will investigate how the C. albicans proteins ASC1 and...
This Project Grant award of $749,594 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to study the role of the host sphingosine kinase 1 (SK1) pathway in controlling infection by the fungus Cryptococcus neoformans (CN) during immunodeficiency. The research will utilize a mouse model of lung cryptococcal granuloma to investigate the immune mechanisms by which the SK1-S1P pathway regulates the...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $2,366,783 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Wisconsin-Madison. The purpose of this 5-year grant is to investigate the molecular processes involved in the germination and pathogenesis of Cryptococcus spores, which can cause fatal fungal infections in immunocompromised individuals. The research aims to: 1) determine the pathways required for spore...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $2,797,623 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to The Regents of the University of California, San Francisco (UCSF) to conduct research aimed at understanding the significance of pathogen genetic variation and evolution. The grant, with a period of performance from July 2024 to May 2029, will utilize a combination of genetics and experimental evolution to investigate complex epistasis...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $170,000.00 to Prokaryotics Incorporated to conduct research focused on developing novel antifungal therapeutics. The research aims to perform structural elucidation of key fungal enzymes involved in glycosylphosphatidylinositol (GPI) biosynthesis, and use those insights to guide the synthesis and evaluation of new...
This Project Grant award of $515,875 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to elucidate the mechanisms by which the fungus Cryptococcus neoformans and its polysaccharide capsule component glucuronoxylomannan (GXM) interfere with neuronal physiology and contribute to cognitive impairment in the setting of CD4 T cell deficiency. The primary objectives are to: 1) determine how...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will provide $265,650 to study the evolutionary dynamics of the opportunistic fungal pathogen Candida glabrata in the gastrointestinal tract. The research aims to elucidate how antifungal drug treatment and immune dysfunction impact the adaptation and resistance development of gut-colonizing C. glabrata populations. Using a...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), provides $284,184 to Duke University to investigate the role of the enzyme CuZnSOD1 in sensing copper-deficient conditions in the fungus Candida albicans. The research aims to further the understanding of the copper homeostasis response pathway in C. albicans, which is critical for its survival as a human pathogen....