This federal Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to characterize a novel cytochrome protein that may allow persistent bacterial pathogens like Burkholderia pseudomallei to evade host-produced nitric oxide. The $216,165 award, with a performance period from Apr 2025 to Mar 2027, aims to: 1) Characterize the phenotype of disruption mutants...
This federal Project Grant award for $637,275 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to uncover the mechanisms behind how gram-negative bacterial pathogens rapidly develop tolerance to chemical stressors like antibiotics. The research aims to determine how bacteria can inhibit the functioning of existing porin proteins in their outer membrane within minutes of exposure to...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $176,152 to Rutgers, The State University of New Jersey to study host-pathogen interactions and carbon processing in glycerol kinase deficient Mycobacterium tuberculosis. The goal is to identify new drug targets to improve the efficacy of tuberculosis (TB) treatment, as drug-tolerant TB strains are a major challenge....
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $569,210 to the University of Colorado Boulder to characterize the biochemical mechanisms of antimicrobial resistance in Gram-negative bacteria. The project aims to structurally and functionally analyze three key enzymes involved in modifying the bacterial cell membrane component lipid A, which confers...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $813,373 in funding to Rutgers, The State University of New Jersey to conduct research on developing new classes of pyrazinoic acid prodrugs against pyrazinamide-resistant Mycobacterium tuberculosis. The key goals of this 5-year research project are to characterize the diverse set of Mycobacterium tuberculosis amidases...
This federal Project Grant award, totaling $1,117,491.00, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award supports a research project led by the University of Illinois that combines molecular biology and microfluidic technology to investigate how host-relevant shear flow impacts stress responses and surface adhesion of the human pathogen Pseudomonas aeruginosa. The key research...
This $783,557 federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will support research to examine the molecular determinants and functions of bacterial polysaccharide cellular localization in Pseudomonas aeruginosa (PA) biofilms. The research aims to determine how the PSL and PEL exopolysaccharides exist in different chemical forms and how their cellular localization is...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will provide $784,217 to the Research Foundation of the City University of New York (RFCUNY) - Lehman College to conduct research characterizing how cellular death signaling pathways contribute to both protective and injurious inflammation during bacterial infections. The research aims to identify novel signaling mechanisms...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $474,363 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Rowan University. The grant, awarded on Dec 20, 2024, supports the development of novel antimicrobial peptides based on the clinically approved molecule daptomycin. The research aims to improve the sequence-structure-activity relationship and synthetic processes for these peptides by incorporating non-canonical amino acids....
This $2,734,799 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research on the respiration and fitness of Bacteroides bacteria in the human gut. The key objectives are to study the NUO respiratory complex, menaquinone biosynthesis, and the NRFHA complex in Bacteroides to better understand their energy generation processes and how they support bacterial fitness in the gut...