Project Grant K22AG088111
- Federal Project Grant Award Summary Emory University received a $147,656 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), with an award date of March 11, 2025 and project completion date of September 29, 2025. The grant supports the development of the first human locus coeruleus (LC) organoid model to advance understanding of Alzheimer's disease (AD) pathology. The research addresses a critical gap in AD knowledge by utilizing...
- Federal Project Grant Award Summary Emory University received a $528,876 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), effective June 1, 2025 through March 31, 2030. This award supports the development and application of novel analytical tools to investigate cis- and trans-genetic regulation of brain transcriptomics and proteomics associated with Alzheimer's disease and related dementias (AD/ADRD). The research extends current...
- Federal Grant Award Summary The National Institute on Aging awarded the University of North Carolina at Chapel Hill a Project Grant totaling $426,674 under the Aging Research program (CFDA 93.866), effective September 1, 2025, through August 31, 2027. This research initiative investigates the implications of long-range mossy cell signaling and connectivity in Alzheimer's disease (AD), with a focus on understanding how glutamatergic mossy cells in the dentate gyrus regulate hippocampal...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Boston University Medical Campus a $636,342 project grant effective August 1, 2025 through April 30, 2030 under the Aging Research program (CFDA 93.866). This project grant supports multiscale modeling and empirical studies examining normal and pathological brain aging, specifically investigating myelin dystrophy, synaptic loss, and neuronal hyperexcitability in the neocortex as they relate to age-related cognitive...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded University of California, San Diego $3,138,871 under the Aging Research program (CFDA 93.866) to conduct a comprehensive four-year research project examining human neuropeptide transmitter systems in Alzheimer's disease (AD) pathogenesis. The project, initiated September 15, 2025 and concluding August 31, 2029, will deliver scientific research services focused on defining the complete repertoire of human brain...
- Federal Project Grant Award Summary Augusta University Research Institute, Inc. (AURI) received a $542,699 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective January 1, 2026 through December 31, 2030. The award funds biomedical research investigating epigenetic mechanisms underlying the selective vulnerability of parvalbumin-positive neurons in the entorhinal cortex during aging and Alzheimer's disease (AD) progression. The research...
- Federal Project Grant Award Summary Duke University's Office of Research Administration is conducting a five-year research project funded by the National Institute on Aging under the Aging Research program (CFDA 93.866), with $493,972 obligated for the project period spanning January 1, 2026, through December 31, 2030. The project, titled "Cell Type-Specific Epitranscriptomic Regulation in the Brain in Aging and Alzheimer's Disease," focuses on understanding how adenosine methylation...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded a $3.22 million Project Grant under the Aging Research program (CFDA 93.866) to the University of California, Irvine on September 15, 2025, for research investigating the role of the retrosplenial cortex (RSC) in Alzheimer's disease (AD) pathogenesis. The project, which extends through August 31, 2029, will deliver scientific research products including characterization of neuronal hyperexcitability mechanisms in...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded $3.23 million through its Aging Research program (CFDA 93.866) to the University of Kansas Center for Research Inc. for a project grant extending from September 30, 2025, through August 31, 2029. The award supports investigative research examining the interplay between neuronal activity, synaptic dysfunction, and mitochondrial abnormalities in Alzheimer's disease. The research will utilize mouse models of...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded The Washington University a $593,146 Project Grant under the Aging Research program (CFDA 93.866) effective January 1, 2026 through November 30, 2030. The project, titled "Mechanisms of Activity-Dependent Transcription and DNA Repair in Neuronal Longevity," supports fundamental research aimed at defining new mechanisms that promote neuronal deoxyribonucleic acid (DNA) repair and transcriptional fidelity across...
The National Institute on Aging (NIA) awarded $198,352.00 to the University of Georgia Research Foundation under the Aging Research program (CFDA 93.866) on March 15, 2026, for research extending through February 28, 2029. This project grant supports scientific investigation into the molecular determinants of age-related cognitive decline, specifically examining the basal forebrain cholinergic neuron (BFCN) to lateral entorhinal cortex (LEC) circuit. The research employs transcriptomics, high-resolution microscopy, and behavioral assays to identify molecular signatures of vulnerability in neural systems affected by aging and Alzheimer's disease pathology. The deliverables include comprehensive characterization of gene expression profiles in young and aged BFCNs and LEC neurons, identification of LEC-projecting cholinergic neurons, and evaluation of behavioral and neurobiological consequences of targeted disruption to this circuit. The project will produce scientific findings regarding the sequence of molecular events that render the BFCN-to-LEC circuit particularly susceptible to age-related degeneration, with implications for understanding early cognitive impairment and developing intervention strategies. Findings will advance understanding of cholinergic system vulnerability in aging and neurodegenerative disease, supporting the NIA's mission to prevent and treat Alzheimer's disease and related dementias.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $198.4k | 3/19/26 |