Project Grant R01AG099139
- This federal Project Grant award of $509,413.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to conduct research on the role of epitranscriptomic regulation of microglial cells in the development and progression of Alzheimer's disease (AD). The project will investigate how methylation of adenosine residues in mRNA (m6A modification) and its regulatory proteins are altered in the brains of AD patients, and how these changes impact microglial function and the brain's...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $493,972.00 to Duke University to conduct research on the role of epitranscriptomic regulation, specifically mRNA methylation (m6A), in brain aging and Alzheimer's disease. The research aims to determine how age-dependent differential methylation of mRNAs in the brain influences the expression of Alzheimer's-associated genes, and to identify the m6A "reader" proteins that mediate these...
- The Project Grant award titled "ENHANCER-AAVS TO MONITOR AND RESTORE CELL-TYPE SELECTIVE INHIBITORY DEFICITS AND CIRCUIT DYSFUNCTION IN HUMANIZED ALZHEIMER'S DISEASE MODELS" was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The $1,459,072.00 award, granted to the J. David Gladstone Institutes, aims to monitor and manipulate inhibitory interneuron cell populations in mouse models to assess their contribution to...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $804,450.00 to support research conducted by the J. David Gladstone Institutes in San Francisco, CA aimed at "Targeting NELL2 and GABAergic Dysfunction to Mitigate ApoE4-Driven Pathogenesis in Alzheimer's Disease." The research will investigate how the Alzheimer's disease risk factor ApoE4 interacts with sex and aging to contribute to neuronal network hyperactivity and cognitive...
- This $426,674 federal grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), supports research to investigate the implications of long-range mossy cell signaling and connectivity in Alzheimer's disease (AD). The project aims to identify ways to remediate the cognitive and emotional impairments associated with AD, with a focus on understanding the role of the dentate gyrus (DG) region of the hippocampus and the activity of glutamatergic mossy...
- This $498,709 Project Grant, awarded by the National Institute on Aging (CFDA 93.866 Aging Research program) on August 20, 2025, supports Epoch Biotech, LLC's research to develop an ApoE-targeted antibody that can modulate the interaction between ApoE and glycosaminoglycans as a potential therapeutic for Alzheimer's disease. The project aims to assess the preclinical efficacy of this antibody approach, leveraging insights from a unique study subject with a genetic variant that conferred...
- This federal Project Grant award of $716,579, awarded by the National Institute on Aging (CFDA 93.866 - Aging Research), supports research to investigate the role of microglia, the immune cells of the brain, in the progression of Alzheimer's disease (AD). Specifically, the research aims to genetically dissect the relationships between different activated states of microglia and their involvement in complement-mediated synapse loss, which is a key neurobiological driver of cognitive decline in...
- This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $4,041,438 to develop new computational tools and biomarkers for Alzheimer's disease. The University of Miami will aggregate and analyze DNA methylation datasets to identify age-associated epigenetic changes related to aging and Alzheimer's progression. Researchers will create a searchable web interface to disseminate findings on the role of DNA...
- This federal Project Grant award of $307,000.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to conduct a single, highly powered study to identify memory processes that are most sensitive to the asymptomatic, preclinical stage of Alzheimer's disease (AD) pathology. The study combines a continuous report item-location associative memory task with advanced behavioral and neural modeling to estimate subtle changes in memory precision that may differentiate healthy...
- This federal Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) provides $2,173,794 to The General Hospital Corporation (Massachusetts General Hospital) to conduct research on enhancing brain resilience to Alzheimer's disease by targeting adult hippocampal neurogenesis. The project aims to explore the mechanisms by which adult hippocampal neurogenesis cooperates with brain-derived neurotrophic factor (BDNF) to potentially slow cognitive decline in...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $542,699 to the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) to conduct research on the epigenetic mechanisms underlying the selective vulnerability of entorhinal parvalbumin-positive GABAergic neurons during aging and Alzheimer's disease progression. The research project aims to determine whether the histone methyltransferase EZH2 is a critical factor in regulating the survival of these vulnerable neurons, and how its dysregulation may contribute to neuropathological changes and cognitive decline. The project will run from January 1, 2026 to December 31, 2030, with the goal of advancing scientific understanding of the molecular pathways driving entorhinal cortex neuron dysfunction and degeneration in Alzheimer's disease.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $542.7k | 12/24/25 |