Project Grant K22AG081276

Award Date 5/1/25
Completion Date 4/30/28
Dollars Obligated $200K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
California, USA
Similar Awards
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) in the amount of $2,433,859 supports research at The Johns Hopkins University to investigate age-related hearing loss and cognitive decline. The key objectives are to study the molecular, cellular, and connectivity changes in the central auditory system during normal aging and Alzheimer's disease, with the goal of developing targeted therapeutic strategies. The research integrates single-cell sequencing,...
This National Institute on Aging (NIA) Project Grant (CFDA 93.866 - Aging Research) aims to evaluate the associations between hearing loss and cognitive/brain health outcomes in middle-aged adults. The $262,975 award to Kaiser Foundation Hospitals, effective from September 1, 2024 to June 30, 2026, will leverage data from the Coronary Artery Risk Development in Young Adults (CARDIA) study to examine whether hearing loss is linked to cognitive test scores and brain volumes in a diverse, midlife...
This federal Project Grant award of $783,083 from the National Institute on Aging's Aging Research program (CFDA 93.866) supports a study to evaluate the effects of cochlear implants versus hearing aids on cognitive function in older adults with age-related hearing loss. The study aims to compare real-world outcomes across several domains, including auditory function, cognitive performance, social interaction, and psychosocial well-being. It will also assess the longitudinal impacts of these...
This $208,750 Project Grant award from the National Institute on Deafness and Other Communication Disorders (CFDA 93.173) will fund research at The General Hospital Corporation (Massachusetts General Hospital) to investigate the role of connectivity between the hippocampus and auditory cortex in comprehending degraded speech. The project will use high-resolution 7 Tesla fMRI to characterize the layer-specific connectivity between these brain regions during listening tasks with varying levels...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) for $1,183,821 will support a 5-year study by Dartmouth College to investigate the relationship between auditory function and Alzheimer's disease (AD) pathophysiology. The research aims to determine if peripheral and/or central auditory test performance can predict the longitudinal accumulation of amyloid-beta and tau proteins in the brain, as well as cognitive decline, among individuals with mild...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a research initiative focused on examining the relationship between hearing loss, language acculturation, and cognitive decline among Hispanic adults in the United States. The $245,625 award, valid from September 1, 2024 to May 31, 2026, will enable researchers at The Johns Hopkins University to pursue three key objectives: 1) Assess whether the association between hearing loss and cognitive...
The National Institute on Aging awarded a $349,016 Project Grant under its Aging Research program (CFDA 93.866) to The University of Texas at San Antonio (UTSA) to research the mechanisms underlying the relationship between high-level cognition and perception in normal aging. The project aims to test two key hypotheses: 1) whether attention control and effort, which decline with age, serve as common mechanisms linking perception and cognition, and 2) whether sensory deprivation, particularly...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $212,095 aims to investigate changes in cholinergic modulation during aging and their impact on neural network activity and memory function in the hippocampus of young and aged mice. The key deliverables include: Acquiring high-quality experimental data on neural firing patterns and cholinergic dynamics in the hippocampal CA3 region of mice performing a spatial memory task, using...
This $443,758 Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) to Northwestern University aims to evaluate the use of over-the-counter (OTC) hearing aids for improving communication outcomes in older adults with mild cognitive impairment (MCI) or early Alzheimer's disease and related dementias (ADRD). The study will run from September 2023 to August 2025. Under this award, Northwestern University will lead a randomized trial to compare the communication...
This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under CFDA Program 93.173 "Research Related to Deafness and Communication Disorders", will fund research to investigate the neural mechanisms underlying how older adults use linguistic context to facilitate speech recognition, especially in noisy environments. The $955,590 award to McMaster University in Canada will utilize cutting-edge neuroimaging techniques such as EEG and...

This federal Project Grant award of $200,385 from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of California, San Diego (UCSD) will investigate the association between hearing impairment, hippocampal function, and memory in middle-aged and older adults. The central hypothesis is that hearing impairment is linked to poorer hippocampal function and memory performance. The project aims to use UK Biobank data to analyze the relationship between hearing, hippocampal activity, and memory, as well as collect pilot data examining associations between hearing impairment, hippocampal fMRI activation, amyloid-beta deposition, and memory in 30 cognitively normal older adults. The findings are expected to provide critical evidence on the connection between hearing impairment and dementia risk, and inform future hearing-based interventions as part of a comprehensive approach to reducing Alzheimer's disease risk. The award will support the career development of the Principal Investigator, Dr. Megan Fitzhugh, toward becoming a leading researcher at the intersection of auditory neuroscience and Alzheimer's disease.

Generated 5/13/25, 2:21 AM