Project Grant R21AG089091

Award Date 9/1/24
Completion Date 5/31/26
Dollars Obligated $675K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Baltimore, MD 21205, USA
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This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) in the amount of $2,433,859 supports research at The Johns Hopkins University to investigate age-related hearing loss and cognitive decline. The key objectives are to study the molecular, cellular, and connectivity changes in the central auditory system during normal aging and Alzheimer's disease, with the goal of developing targeted therapeutic strategies. The research integrates single-cell sequencing,...
This Project Grant award from the National Institute on Aging (CFDA 93.866, Aging Research) will fund a $472,172 study by Kaiser Foundation Hospitals to evaluate the associations between hearing loss and cognitive and brain health outcomes in middle-aged adults. The study will leverage data from the Coronary Artery Risk Development in Young Adults (CARDIA) longitudinal cohort, including measures of audiometric hearing loss, cognitive test scores, and structural brain MRI. The goals are to...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $200,385 to the University of California, San Diego (UCSD) to investigate the association between hearing impairment, hippocampal function, and memory in middle-aged and older adults. The overarching goal is to better understand how hearing impairment may be a modifiable risk factor for Alzheimer's disease and dementia. Specifically, the funded project will leverage data from the...
This Project Grant award of $698,032 from the National Institute on Aging (NIA) under CFDA 93.866 Aging Research will fund a multi-year study at The University of Texas at San Antonio (UTSA) to investigate the mechanisms linking high-level cognition and perception, particularly in the auditory domain, during normal aging. The project aims to test two key hypotheses: 1) that attention control and effort, which decline with age, are common mechanisms linking perception and cognition, and 2) that...
This federal Project Grant award, funded by the National Institute on Aging (CFDA 93.866 - Aging Research), is focused on understanding the effectiveness of cochlear implants and hearing aids in real-world settings for older adults with age-related hearing loss (ARHL), both with and without mild cognitive impairment or dementia. The $1,495,307 award, which runs from September 1, 2024 to June 30, 2029, will collect real-world data via a smartphone ecological momentary assessment (EMA) system to...
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This project grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $4,131,388 to study cognitive aging, brain morphology, and arrhythmias in Hispanics/Latinos. The Regents of the University of Minnesota receive the award as the primary awardee, with subawards to Albert Einstein College of Medicine, Johns Hopkins University, University of Miami, University of Illinois, University of California San Diego, San Diego...
This federal Project Grant award of $601,672 from the National Institute on Deafness and Other Communication Disorders (NIDCD) under CFDA program 93.173 "Research Related to Deafness and Communication Disorders" will support research to better understand the relationship between aging, brain integrity, and chronic aphasia among stroke survivors. The key objectives of the 5-year research project are to: 1) examine the influence of cardiovascular risk factors and protective cognitive...
This federal Project Grant award of $477,660 from the National Institute on Deafness and Other Communication Disorders (CFDA 93.173 - Research Related to Deafness and Communication Disorders) supports research to investigate age-related brain differences that affect speech recognition in older adults. The primary objectives are to characterize how quickly older adults accumulate sensory evidence and how much evidence they require to make speech recognition decisions, and to link these perceptual...
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This Project Grant awarded by the National Institute on Aging (NIA), under CFDA 93.866 Aging Research, aims to investigate the role of language acculturation in the association between hearing loss and cognitive function among Hispanic adults in the United States. The $675,469 award, effective September 1, 2024 through May 31, 2026, will be administered by The Johns Hopkins University.

The research project has three specific aims: 1) Examine whether the association between hearing loss and cognitive decline over approximately six years differs by levels of language acculturation among Hispanic adults; 2) Investigate the association between hearing loss and brain health markers on MRI scans, and whether language acculturation moderates these associations; and 3) Explore the link between hearing loss and Alzheimer's disease pathology markers, assessing the role of language acculturation. This work aims to inform public health efforts and raise awareness about interventions that can mitigate the effects of hearing loss and cognitive decline in the Hispanic community.

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