This $2,248,793 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund research to investigate the relationship between epigenetic aging and patient outcomes after severe traumatic brain injury (TBI). The University of Pittsburgh, the award recipient, will expand upon their preliminary work indicating that accelerated epigenetic aging, as measured by DNA methylation changes, is linked to variations in patient outcomes up to 2 years after severe TBI. The...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $3,102,638.00 in funding to The Trustees of the University of Pennsylvania to develop novel gyrencephalic animal models that recapitulate the neuropathological and clinical features of post-traumatic brain injury (TBI) neurodegeneration, including Alzheimer's disease and related dementias (ADRD). The key objectives are to establish three distinct TBI injury paradigms in gyrencephalic species...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $4,619,796.00 to the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) to conduct research on the relationship between traumatic brain injury (TBI) and the accelerated progression of Alzheimer's disease (AD). The key objectives of this 3-year research project are to: 1) Determine the impact of pulsed laser therapy on TBI-accelerated AD pathogenesis in an...
This federal Project Grant award of $2,283,334 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports the development and validation of a murine model of Traumatic Brain Injury (TBI)-induced Alzheimer's Disease and Related Dementias (ADRD). Led by the Morehouse School of Medicine, this "Team Science" collaborative project aims to systematically evaluate mouse strain determinants and TBI injury types to identify an optimized model that recapitulates key progressive...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, will fund research at the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) to investigate the mechanisms linking traumatic brain injury (TBI) to subsequent neurodegeneration and dementia. The $1,975,262 award will support a 3-year study...
The National Institute on Aging (NIA) awarded a $3,109,079 Project Grant titled "Modeling the Role of Age at Traumatic Brain Injury in the Development of Alzheimer's Disease and Related Dementias" under the Aging Research Federal Grant Program (CFDA 93.866). The award will support a project led by the Regents of the University of California at Riverside to investigate how traumatic brain injury (TBI) at different ages impacts the progression of Alzheimer's disease and related dementias...
This federal Project Grant award, funded by the National Institute on Aging (CFDA 93.866: Aging Research), supports research to understand the mechanisms driving the chronic effects of repetitive mild traumatic brain injury (r-mTBI) and its link to Alzheimer's disease. The $449,460 grant, awarded on June 15, 2024, will be performed by The Roskamp Institute, Inc., a non-profit research organization in Sarasota, Florida. The research aims to investigate how aberrant PTEN signaling in chronically...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $236,850 to Rosalind Franklin University of Medicine & Science to investigate the role of neprilysin-like enzymes in traumatic brain injury (TBI) and the development of dementia. The project aims to use transgenic mouse models to examine the short-term and long-term effects of altering the activity of neprilysin and neprilysin-2 enzymes in the context of TBI. The research seeks to...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $243,000 in funding to The Regents of the University of California, San Francisco (UCSF) to conduct a 5-year research study investigating the relationship between delirium and biological aging in older adults with traumatic brain injury (TBI). The primary objectives are to identify whether biological age metrics are associated with post-traumatic delirium, determine if delirium impacts...
This federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate the relationship between traumatic brain injury (TBI), hematopoietic stem cell (HSC) dysfunction, chronic neurodegeneration, and Alzheimer's disease. The award, totaling $102,948.00, will be executed by Case Western Reserve University over the...