This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will provide $655,329 to Albert Einstein College of Medicine to investigate the role of the GPNMB gene in the pathogenesis of Parkinson's disease, Lewy body dementia, and related synucleinopathies. The 5-year research project aims to identify causal genetic variants that regulate GPNMB...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $499,286.59 to the University of Pittsburgh to conduct research on the role of the LRRK2 protein in Parkinson's disease pathogenesis. The research aims to elucidate how wild-type LRRK2 kinase activity is stimulated, its translocation to mitochondria under oxidative stress...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $646,104 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the San Diego Biomedical Research Institute, a non-profit research organization. The grant supports research to investigate how neuroinflammation mediated by the interleukin-13 receptor signaling pathway may contribute to the selective loss of dopaminergic neurons in Parkinson's disease. The...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $163,750.00 to The Johns Hopkins University to conduct research on novel small molecule enhancers that can boost the activity of the glucocerebrosidase 1 (GBA1) enzyme. The research aims to identify promising drug candidates that can treat Parkinson's disease (PD) and...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,641,495.00 to the University of Florida to investigate the intersection of the GBA and LRRK2 genes in Lewy body dementia (LBD). The project aims to understand the molecular mechanisms by which GBA1 mutations influence the regulation, trafficking, and maturation of key lysosomal proteins involved in the metabolism of alpha-synuclein, as well as the impact on gamma-secretase and amyloid...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,707,089 to Northwestern University to conduct research aimed at synergistically enhancing endoplasmic reticulum (ER) proteostasis, protein trafficking, and lysosomal activity as potential treatments for dementia with Lewy bodies (DLB) and Parkinson's disease-dementia (PDD). The research will use patient-derived induced pluripotent stem cell (iPSC) neuron models and mouse models to test the...
This $670,600 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research to better understand the role of microglia, a type of immune cell in the brain, in the onset and progression of Parkinson's disease (PD). The research aims to determine whether increased density of the colony stimulating factor 1 receptor (CSF1R), a marker of...
This federal Project Grant award, with ID R21AG089563, was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The total award amount is $237,160.00 and the project period runs from August 15, 2024 to May 31, 2026. The overarching goal of this project is to investigate the role of striatal astrocytic dopamine D2 receptor (D2R) signaling in the pathogenesis of Parkinson's disease (PD) caused by LRRK2 gene mutations. The research aims...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), is funding advanced scientific research on the role of interleukin-13 receptor signaling in neurodegeneration. The $741,976 award supports a project to investigate how activation of the interleukin-13 receptor alpha 1/interleukin-4 receptor alpha (IL-13RA1/IL-4RA) heterodimer...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $231,826.00 to Duquesne University to conduct research on the role of microglia/macrophages in Lewy body disorders. The primary objectives are to: 1) identify the neural cell type most likely to harbor alpha-synuclein aggregates and determine if these cells can be...