Project Grant R21AG089563
Award Date
8/15/24
Completion Date
5/31/26
Dollars Obligated
$237K
Federal Agency
National Institute on Aging
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Illinois, USA
Similar Awards
This federal Project Grant award of $227,205, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate the effects of the Parkinson's disease-associated protein LRRK2 on lysosomal function and inflammatory activity in microglia. The research, conducted by Northwestern University, aims to: 1) examine how LRRK2 and the Parkinson's...
This $1,707,089 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund research by Northwestern University to investigate synergistic approaches for enhancing endoplasmic reticulum (ER) proteostasis, protein trafficking, and lysosomal activity as potential treatments for dementia with Lewy bodies and Parkinson's disease-dementia. The research will use patient-derived induced pluripotent stem cell neuron models and mouse models to test the effects of...
This federal Project Grant award of $2,208,982 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to investigate the role of the interleukin-13 receptor in Parkinson's disease. The research aims to determine the molecular and cellular mechanisms by which activation of the interleukin-13 receptor alpha 1 (IL-13RA1) can affect the survival of dopaminergic...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $646,104 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the San Diego Biomedical Research Institute, a non-profit research organization. The grant supports research to investigate how neuroinflammation mediated by the interleukin-13 receptor signaling pathway may contribute to the selective loss of dopaminergic neurons in Parkinson's disease. The...
This $2,069,215 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research by Case Western Reserve University to investigate the role of the beta-arrestin2-LMBRD2 pathway in the transmission and toxicity of pathological alpha-synuclein, which is a defining hallmark of Lewy body diseases such as Parkinson's disease and dementia with Lewy bodies. The research will utilize cellular and animal models to study the mechanisms by which beta-arrestin2...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to characterize the role of the sigma-1 receptor (SIGMAR1) in regulating astrocyte pro-inflammatory activities and their interactions with microglia in Parkinson's disease (PD). The $107,948 award, effective October 1, 2024 through December 1, 2027, will enable the University of Rochester to: 1) Evaluate the impact of SIGMAR1 on astrocyte and astrocyte-microglia pro-inflammatory...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to examine the role of the LRP10 gene in Parkinson's disease, Parkinson's disease dementia, and dementia with Lewy bodies. The $457,875 award, granted on May 1, 2025, will fund the generation and characterization of an LRP10 knockout mouse model to investigate the physiological functions and pathological roles of LRP10 in these neurodegenerative disorders. The research, conducted by the...
This federal Project Grant award, identified as F31NS137765, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The $173,140 grant, awarded on Sep 30, 2024, supports research to investigate the role of neural activity in the degeneration of midbrain dopamine neurons, which is a key pathological process in Parkinson's disease. The project will utilize...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to establish the role of alpha-synuclein-mediated membrane permeabilization in the spread of alpha-synuclein aggregates related to Parkinson's disease and related dementias. The $406,260 award to Purdue University will leverage fluorescence lifetime imaging microscopy...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under CFDA program 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders, provides $670,600 to The Johns Hopkins University to conduct research on the role of microglia in Parkinson's disease (PD) cognitive and motor impairment. The research aims to better understand the relationship between a microglial-specific radioligand, [11C]CPPC, and the severity of...