Project Grant R21MH141473
- This Project Grant award of $396,250 from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants (CFDA 93.242) program, will support research at Vanderbilt University to investigate the regulation of metabotropic glutamate receptor (mGluR) activity by protein-protein interactions. The research aims to: 1) test a suite of agonists, positive allosteric modulators (PAMs), and negative allosteric modulators (NAMs) for activity at mGluR7 with and without the protein...
- This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $435,875 to Vanderbilt University to identify the molecular signatures of metabotropic glutamate (mGlu) receptor heterodimers. The project aims to investigate the role of mGlu7 receptor heterodimerization and its impact on receptor pharmacology, with a focus on understanding its implications for neurodevelopmental disorders like Rett...
- This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $706,404 to Thomas Jefferson University to conduct research on the pathophysiological roles of protein-protein interactions at excitatory synapses and their modifications in schizophrenia. The research aims to determine how defects in protein-protein interactions drive NMDA receptor hypofunction, a key aspect of the synaptic pathology in...
- This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), will provide $197,640.00 to The Johns Hopkins University to investigate the functional consequences of schizophrenia-associated genetic variants in the GRIA3 gene, which encodes a key subunit of the AMPA receptor. The goal is to better understand the pathological mechanisms underlying schizophrenia, with the ultimate aim of identifying new therapeutic...
- This federal Project Grant award of $237,399 from the National Institute of Neurological Disorders and Stroke (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) supports research by Vanderbilt University to investigate the role of the metabotropic glutamate receptor 7 (mGluR7, GRM7) as a potential genetic modifier of cognitive deficits in neurofibromatosis type 1 (NF1). The research aims to understand how variations in the GRM7 gene may impact learning...
- This federal Project Grant award, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), will support research to characterize a genetic mouse model for a gene implicated in neurodevelopmental disorders including autism, intellectual disability, and schizophrenia. The $742,484 award, with a project period from January 13, 2025 to October 31, 2029, will fund experiments to obtain multiome single nucleus RNA-sequencing,...
- This federal Project Grant award of $647,833 from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), supports research conducted by Northwestern University to investigate cellular mechanisms underlying excitation/inhibition imbalance in the medial prefrontal cortex as a convergent pathogenic mechanism across genetic mouse models relevant to schizophrenia. The key research objectives are to: 1) determine the reversal potential of the...
- This federal Project Grant award of $136,050.00, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research to investigate how a specific protein, BTBD11, regulates the function and composition of glutamatergic synapses in interneurons. The research aims to elucidate the role of BTBD11 and liquid-liquid phase separation in maintaining the unique properties of glutamatergic synapses in interneurons, which are...
- This federal Project Grant award of $774,632 was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The award supports research to understand how changes in dopamine signaling impact neural circuits and contribute to symptoms like impaired cognition and perception in dopamine-associated neuropsychiatric diseases. The key objectives are to use in vivo imaging to determine how selectively activating dopamine neurons in the...
- This Project Grant award of $735,932 from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), aims to elucidate the cellular manifestations of positive symptoms, such as auditory hallucinations, in mouse models of two strong genetic predictors of schizophrenia - 22q11.2 microdeletion syndrome and 3q29 microdeletion syndrome. The research will focus on disruptions in thalamocortical projections between the auditory thalamus and auditory...
This federal Project Grant award, funded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research to investigate the role of group III metabotropic glutamate receptors (mGlu4/7/8) in modulating glutamatergic signaling and their potential as targets for treating schizophrenia. The $217,818 award to Vanderbilt University, effective from September 9, 2025 to September 8, 2027, will fund studies to use pharmacological and optogenetic tools to further elucidate the circuit-specific mechanisms by which activation of these receptors can affect schizophrenia-relevant physiological and behavioral deficits in rodent models. The research aims to provide mechanistic insights into the genetic associations between mGlu4/7 receptor polymorphisms and schizophrenia risk, as well as explore the potential of agents modulating these receptors for providing symptomatic relief in schizophrenia patients.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $217.8k | 9/8/25 |