Project Grant R16GM159167
- This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), will provide $197,640.00 to The Johns Hopkins University to investigate the functional consequences of schizophrenia-associated genetic variants in the GRIA3 gene, which encodes a key subunit of the AMPA receptor. The goal is to better understand the pathological mechanisms underlying schizophrenia, with the ultimate aim of identifying new therapeutic...
- This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $706,404 to Thomas Jefferson University to conduct research on the pathophysiological roles of protein-protein interactions at excitatory synapses and their modifications in schizophrenia. The research aims to determine how defects in protein-protein interactions drive NMDA receptor hypofunction, a key aspect of the synaptic pathology in...
- This Project Grant award from the National Institute of Mental Health (NIMH), under the federal Mental Health Research Grants program (CFDA 93.242), provides $804,690 to The Johns Hopkins University to determine the relationship between N-acetyl-aspartyl-glutamate (NAAG) levels and memory deficits in schizophrenia patients in mid- to late-life. The project aims to measure NAAG levels using magnetic resonance spectroscopy and correlate them with declarative and working memory performance in...
- This federal Project Grant award, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), will support research to characterize a genetic mouse model for a gene implicated in neurodevelopmental disorders including autism, intellectual disability, and schizophrenia. The $742,484 award, with a project period from January 13, 2025 to October 31, 2029, will fund experiments to obtain multiome single nucleus RNA-sequencing,...
- This $129,290 Project Grant awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support research at Massachusetts General Hospital (MGH) to analyze phenotypic, genetic, and neurobiological data from over 43,000 participants with autism spectrum disorder (ASD) and schizophrenia (SCZ). The goal is to better understand how genetic variation associated with intellectual disability, ASD, and SCZ maps onto developmental...
- This Project Grant award of $3,498,931.00 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) aims to comprehensively investigate the impact of loss of 100 neurodevelopmental and psychiatric disorder (NPD) genes in mice. The project, titled "Cross Scale Interrogation of NPD Genes (SING) in Mice", will utilize knockout mouse models to examine gene expression, cellular changes, neural circuits, and behaviors across multiple...
- The federal Project Grant award of $420,984.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to develop statistical methods for analyzing deep mutational scanning (DMS) data. The research aims to improve the interpretation of DMS experiments, which can measure how genetic variants affect protein function, in order to better understand the mechanisms underlying basic biology and...
- This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $714,615 to New York University School of Medicine to conduct research on dissecting the role of non-coding repeats in the genetics of psychiatric disorders like schizophrenia and bipolar disorder. The key objectives are to: Fine map regulatory features of a repeat expansion within the CACNA1C gene, which has been strongly associated with...
- This federal Project Grant award of $844,917 from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), aims to identify and characterize moderate effect size (MES) risk genes that contribute to Autism Spectrum Disorder (ASD) liability and manifestation. The key research objectives are to: (1) identify and characterize MES risk genes using rare and common genetic variation; (2) identify MES risk genes on Chromosome X; (3) identify MES risk...
- This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $811,404 to The Trustees of Columbia University in the City of New York to conduct research on the neural circuitry underlying anticipatory anhedonia in schizophrenia. The research aims to utilize a computational psychiatry approach to dissect the neural mechanisms of altered reward anticipation, which may serve as novel targets for treating...
This $137,060 Project Grant award from the National Institute of General Medical Sciences (CFDA 93.859 - Biomedical Research and Research Training) aims to develop the Platform for Analyzing Mutations Associated with Schizophrenia (PAMS). The key objectives of the project are to: Investigate the impact of missense mutations on protein stability for 12 schizophrenia risk genes using computational modeling and analysis. Predict the effects of mutations on protein-protein interactions by constructing complex structure models and validating through co-immunoprecipitation experiments. Integrate sequence-based machine learning predictors and structure-based calculations into the PAMS platform to analyze mutations in 921 identified schizophrenia-associated genes and provide a comprehensive database and user-friendly interface for collaborative analysis. The project will be conducted by Howard University over the award period of September 1, 2025 to August 31, 2029. The goal is to elucidate the molecular mechanisms underlying schizophrenia by providing insights into the functional effects of rare genetic mutations, while also offering research training opportunities.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $137.1k | 8/12/25 |