This $107,860 Project Grant, awarded by the National Institute of Child Health and Human Development under the Child Health and Human Development Extramural Research program (CFDA 93.865), will support research to understand the functional role of fibroid subtype mutations in developing new targeted therapies for uterine fibroids. The research aims to 1) determine the functional roles of HMGA2 over-expression and MED12 mutation in uterine fibroids, 2) predict and test drug compounds to target...
This Project Grant award, provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under CFDA Program 93.865 - Child Health and Human Development Extramural Research, will support research to estimate the impact of recent state-level reproductive and pregnancy health policy changes, such as the Dobbs v. Jackson Supreme Court decision, on fertility, maternal health, and infant health outcomes over time and across subgroups in the U.S. The $713,558...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $390,000 to Thomas Jefferson University (Sidney Kimmel Medical College) to evaluate the use of contrast-enhanced ultrasound (CEUS) and subharmonic-aided pressure estimation (SHAPE) techniques for assessing uterine fibroids before and after uterine artery embolization (UAE) procedures. The goals...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research to investigate the relationship between early life immune responses and the intergenerational link of cardiometabolic outcomes. The $245,625 award to The Johns Hopkins University aims to: 1) identify early life immune response signatures linked to long-term cardiometabolic health; 2) examine the...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the federal Child Health and Human Development Extramural Research program (CFDA 93.865), will support a $660,773 research project to assess the impact of obesity on the endometrium and the reversibility of these changes with weight loss. The project aims to characterize the molecular and functional impact of obesity on the endometrium, and evaluate the reversibility...
This $2,121,229 Project Grant, awarded by the National Institute of Child Health and Human Development (NICHD) under CFDA 93.865 - Child Health and Human Development Extramural Research, supports research to evaluate the impact of altered gene expression on uterine fibroid risk among women of African ancestry. The key objectives are to: 1) test for associations between known and novel fibroid genetic risk loci and gene expression in Nigerian women, 2) detect cell-specific gene expression...
The National Institute of Child Health and Human Development (NICHD) awarded a 5-year, $1,624,100 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to the University of Kansas Medical Center Research Institute, Inc. The goal of this project is to understand the role of the tumor suppressors REST and MED12 in regulating estrogen and progesterone pathways in uterine fibroids. The research aims to define molecular hallmarks for developing selective...
This federal Project Grant award, valued at $643,049.00 and issued by the National Institute of Child Health and Human Development (NICHD) under CFDA Program 93.865 Child Health and Human Development Extramural Research, will fund the development of a physiomimetic model of the endometrioma lesion microenvironment at the University of Illinois. The research aims to investigate the multicellular interactions and tissue tropism that drive the initiation and invasion of endometriotic lesions, which...
This $178,068 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports a 4-year research plan led by Principal Investigator Dr. Susanna Mitro at Kaiser Foundation Hospitals to investigate the relationship between hypertension, antihypertensive medication use, and uterine fibroid diagnosis. Specifically, the research will: 1) quantify prospective associations between blood pressure trajectories/hypertension onset and...
This Project Grant award, funded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), will support research to develop non-invasive magnetic resonance imaging (MRI) techniques to predict fetal growth early in pregnancy. The $295,212 award, with a project period from September 1, 2024 to August 31, 2026, will be used by the University of South Australia to conduct a preclinical study in...