Project Grant K08DE033494

Award Date 7/1/24
Completion Date 6/30/29
Dollars Obligated $169K
Federal Grant Program
93.121
Assistance Type
Project Grant
Place of Performance
Chapel Hill, NC 27599, USA
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This federal Project Grant award, with ID K08DE033494, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The total funding amount is $169,242 over the award period from July 1, 2024 to June 30, 2029.

The grant supports Dr. Adam Lietzan, a periodontist and research assistant professor at the University of North Carolina at Chapel Hill (UNC-CH), in his research to decipher the mechanisms by which the anti-inflammatory cytokine interleukin-37 (IL-37) regulates periodontal inflammation. The project aims to characterize the cellular pathways modulated by IL-37 in oral epithelial cells during microbial challenge, investigate the molecular interactions between IL-37 and its receptors, and examine the role of glycosaminoglycans in the periodontal extracellular matrix on IL-37 bioactivity. The research findings are expected to inform the development of new or improved IL-37-based interventions for managing chronic inflammation in periodontitis.

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