Project Grant K08CA304353
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded $185,760.00 to The Regents of the University of California, San Francisco under the Cancer Research Manpower program (CFDA 93.398) on July 7, 2025. This Project Grant funds research aimed at enhancing treatment outcomes for metastatic castration-resistant prostate cancer (MCRPC) through the development of novel tumor-targeted combination therapy. The primary research deliverable involves creating a single...
- Federal Grant Award Summary This Project Grant, awarded by the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), supports fundamental research to develop genetically engineered myeloid cell therapies for cancer treatment. The award to The Regents of the University of California, San Francisco, with a project period from August 1, 2025 through July 31, 2028, funds research aimed at overcoming current limitations in treating solid tumors. The project will...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a $421,685 Project Grant to The Regents of the University of California, San Francisco under the Cancer Biology Research program (CFDA 93.396) for research activities spanning August 8, 2025 through July 31, 2027. This award funds a discovery-focused research initiative investigating functional immune niches within the tumor microenvironment (TME) that support effective cancer immunotherapy responses. The primary deliverable...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a $414,402 Project Grant to The Regents of the University of California, San Francisco under the Cancer Treatment Research program (CFDA 93.395) for the period May 1, 2026 through April 30, 2028. This research project develops multi-modality imaging and biomarker integration methods to improve glioblastoma radiation therapy targeting. The deliverables include: (1) white matter infiltrative risk maps derived from diffusion...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a $640,466 Project Grant to The Regents of the University of California, San Francisco under the Cancer Treatment Research program (CFDA 93.395) effective June 1, 2026 through May 31, 2031. This five-year initiative focuses on developing a novel class of covalent protein radiopharmaceuticals for targeted radionuclide therapy in cancer treatment. The project involves designing and genetically incorporating latent...
- Federal Grant Award Summary The University of California, San Francisco (UCSF) received a $729,587 Project Grant from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) awarded August 21, 2025, with completion targeted for July 31, 2030. The project aims to develop a personalized, voxel-wise predictive model for identifying brain metastases risk in non-small cell lung cancer adenocarcinoma patients using multi-parametric magnetic resonance imaging. The...
- Federal Project Grant Award Summary The National Cancer Institute awarded a Project Grant totaling $194,914 under the Cancer Research Manpower program (CFDA 93.398) on September 15, 2025, to support cancer research training and investigator development. This award funds research led by Dr. Xu examining how structural variants (SVs) contribute to oncogene activation in cancer through genome engineering and single-cell sequencing approaches. The project runs through August 31, 2028, and will be...
- Federal Project Grant Award Summary The Leland Stanford Junior University received a $135,774 Project Grant from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398) on July 10, 2025, with a completion date of June 30, 2027. This award supports research training and investigation into tumor suppressor genes (TSGs) and the overdominant model of tumor suppression in oncogenic KRAS-driven lung adenocarcinoma. The research employs advanced molecular and...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded The Regents of the University of California, San Francisco a project grant of $151,040 under the Cancer Research Manpower program (CFDA 93.398) effective January 1, 2026, with completion scheduled for July 31, 2028. The award supports a research initiative titled "Toward Understanding the Functional Landscape of Proteolysis at the Cell Surface," which aims to develop advanced analytical methods and chemical...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded The Regents of the University of California, San Francisco a $680,598 Project Grant under the Cancer Biology Research program (CFDA 93.396) effective September 1, 2025, with a completion date of August 31, 2030. The award supports fundamental research focused on decoding the Cullin-5 (CUL5) E3 ubiquitin ligase complex to engineer therapeutic T cells with enhanced durability and sustained effector function. The project...
The National Cancer Institute (NCI), under its Cancer Research Manpower program (CFDA 93.398), awarded $286,881 to The Regents of the University of California, San Francisco effective May 1, 2026 through April 30, 2031. This K08 Career Development Award supports the research and professional development of Dr. S. John Liu, a second-year assistant professor in residence at UCSF, to train him as an independently funded physician-scientist capable of conducting basic and translational investigation in neuro-oncology. The award funds Dr. Liu's investigation into DNA-PKcs (DNA-dependent protein kinase, catalytic subunit), a kinase whose non-canonical functions in tumorigenesis and tumor-immune signaling remain underappreciated, with application to addressing radiotherapy resistance in glioblastoma (GBM). The research deliverables encompass three integrated aims spanning tumor cell-intrinsic and tumor immune microenvironment mechanisms. Aim 1 investigates how DNA-PKcs drives radiotherapy resistance through transcriptional regulation and interactions between DNA repair and interferon signaling. Aim 2 examines DNA-PKcs regulation of the tumor immune microenvironment using syngeneic animal models and evaluates the cGAS/STING pathway in anti-tumor effects, with potential therapeutic targeting through STING agonism. Aim 3 validates tumor immune microenvironment reprogramming using patient tumor biospecimens from an ongoing clinical trial of DNA-PKcs inhibition combined with radiotherapy for GBM. The award leverages Dr. Liu's prior work employing single-cell functional genomics, CRISPR screens, in vivo perturb-seq, intracranial xenografts, and spatial transcriptomics to identify and validate genetic regulators of radiotherapy resistance.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $286.9k | 4/29/26 |