Project Grant K08CA300357
- The National Cancer Institute awarded The Regents of the University of California, San Francisco $126,747 on January 9, 2026, under the Cancer Research Manpower program (CFDA 93.398) to support research interrogating mechanisms of suppressed progenitor-exhausted CD8 T cell (TPEX) immunotherapy response in metastatic tumor-draining lymph nodes of head and neck cancer patients. The research uses metastatic 4MOSC1 and 4MOSC2 orthotopic mouse models of head and neck cancer to evaluate why TPEX...
- The National Cancer Institute, part of the Department of Health and Human Services National Institutes of Health, awarded $278,197 to The Regents of the University of California, San Francisco on July 20, 2026, under the Cancer Research Manpower program (CFDA 93.398, Project Grant K08CA297137). The award funds development of next-generation cellular therapies targeting acute myeloid leukemia, specifically engineered CAR-T cells and multifunctional anti-CD70 T cell therapies designed to eliminate...
- The National Cancer Institute awarded The Regents of the University of California, San Francisco $132,618 on December 1, 2025, under the Cancer Research Manpower program (CFDA 93.398) to support mentored training for a PhD student in epidemiology at UCSF to become a researcher in cancer health disparities. The award funds a Ruth L. Kirschstein National Research Service Award (F31) that provides the trainee with expertise in translational research, geospatial data analysis, and causal inference...
- The National Cancer Institute awarded The Regents of the University of California, San Francisco $237,546 on July 3, 2026, under the Cancer Research Manpower program (CFDA 93.398) to support research targeting toxin-imposed epigenetic and transcriptional circuits to restore T cell function in cancer immunotherapy. The research combines mechanistic dissection of TOX-dependent regulatory networks with design of programmable synthetic transcription factors to overcome T cell exhaustion, a major...
- The National Cancer Institute awarded $122,679 to The Regents of the University of California, San Francisco on December 1, 2025, under the Cancer Research Manpower program (CFDA 93.398) to support research investigating the role of regulatory T cells (Tregs) and T progenitor exhausted (Tpex) cell interactions in tumor-draining lymph node immunosuppression and immunotherapy response. The project will test the hypothesis that lymph node metastasis amplifies Treg function to create an...
- The National Cancer Institute awarded The Regents of the University of California, San Francisco $172,889 on January 12, 2026, under the Cancer Research Manpower program (CFDA 93.398) to develop and optimize chimeric antigen receptor (CAR) T-cell therapies for acute myeloid leukemia (AML). The funded research applies structure-guided protein evolution to improve natural ligand-based CAR-T therapies targeting CD70 in AML. The project uses computational deep learning algorithms and high-throughput...
- The National Cancer Institute awarded The Regents of the University of California, San Francisco $230,388 on January 1, 2026, under the Cancer Research Manpower program (CFDA 93.398) to support biomedical training and research in cancer biology. The recipient will develop analytical and chemical methods to profile proteolysis on the cell surface, addressing the challenge that cell surface proteins represent only approximately 1% of total cellular proteins and remain understudied due to...
- The National Cancer Institute awarded $306,304 to The Regents of the University of California, San Francisco on July 2, 2026, under the Cancer Research Manpower program (CFDA 93.398) to support Dr. Anita Hargrave's career development as a clinician-investigator in trauma-informed smoking cessation research for women. The project funds Dr. Hargrave's training in advanced statistical analyses, implementation science, and clinical trial design to examine the relationship between psychological...
- The National Institutes of Health National Cancer Institute awarded the Sloan-Kettering Institute for Cancer Research $146,299 on August 1, 2026, under the Cancer Research Manpower program (CFDA 93.398) for a K99 postdoctoral career development grant supporting research into cancer cell surface remodeling and engineered immunotherapy. The funded research investigates how dynamic cell surface changes during cancer progression shape tumor-immune interactions and fibrosis, with particular focus...
- The National Cancer Institute awarded The Regents of the University of California, San Francisco $286,881 on May 1, 2026, under the Cancer Research Manpower program (CFDA 93.398) to support Dr. S. John Liu's K08 Career Development Award for independent physician-scientist training in neuro-oncology. Dr. Liu will investigate the role of DNA-PKcs in radiotherapy resistance and tumor immune signaling in glioblastoma. Aim 1 focuses on tumor cell-intrinsic mechanisms of how DNA-PKcs drives...
The National Cancer Institute awarded The Regents of the University of California, San Francisco $287,320 on September 1, 2026, under the Cancer Research Manpower program (CFDA 93.398) to support clinical research training and career development in cancer research. The award is a K08 Project Grant. The research addresses predictive models and biomarker discovery for immune checkpoint inhibitor treatment outcomes in hepatocellular carcinoma patients. Specifically, the work will refine and externally validate a clinical prediction model of early adverse outcomes in immunotherapy-treated HCC patients, evaluate and discover pre-treatment plasma biomarkers associated with treatment toxicity, and evaluate and discover pre-treatment plasma biomarkers associated with treatment response. The project responds to a clinical gap: up to 25 percent of HCC patients receiving immune checkpoint inhibitors develop severe immune-related adverse events, which pose particular risk for patients with underlying cirrhosis, yet predictors of serious adverse events or treatment response are absent from current literature. The principal investigator, Dr. Li, is a hepatologist at UCSF specializing in hepatocellular carcinoma management and liver immune-mediated toxicities. The work will leverage an ongoing HCC immunotherapy cohort and builds on preliminary data generated through a prior American College of Gastroenterology Junior Faculty Development Award. Performance occurs at UCSF in San Francisco, California, from September 1, 2026, through August 31, 2031. The Cancer Research Manpower program supports biomedical training opportunities for individuals pursuing careers in basic, clinical, and prevention research relevant to the National Cancer Program.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $287.3k | 8/20/26 |