Project Grant K08CA299698
- Federal Grant Award Summary Mayo Clinic received a $667,710 Project Grant award from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) on March 20, 2026, with a completion date of February 28, 2031. The grant supports a randomized Phase 2 clinical trial investigating blood-based biomarkers to optimize treatment strategies for patients with oligometastatic castration-sensitive prostate cancer (OMCSPC). The research evaluates prostate cancer-derived...
- Federal Grant Award Summary Mayo Clinic received a $367,731 Project Grant from the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research program (CFDA 93.393), awarded May 12, 2026, with a completion date of April 30, 2031. The grant supports research investigating ADAR1 (Adenosine Deaminase Acting on RNA 1) protein's role in DNA replication and its potential as a therapeutic target for breast cancer treatment. The research focuses on the nuclear ADAR1P110 isoform's...
- Federal Project Grant Summary Mayo Clinic received a $100,228 Project Grant from the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398), awarded December 1, 2026, with completion targeted for May 5, 2029. This grant supports biomedical research training and investigator development in cancer research aligned with the National Cancer Program's strategic priorities. The award funds research activities at Mayo Clinic's Rochester, Minnesota facility focused on...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded Fred Hutchinson Cancer Center a Project Grant totaling $139,184 under the Cancer Research Manpower program (CFDA 93.398) for the period of July 1, 2025, through June 30, 2027. This award funds research investigating the role of RNA components of the translation apparatus in prostate cancer plasticity and therapy response. The project focuses on elucidating how prostate cancer leverages transfer RNA (tRNA) and 5'...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded Fred Hutchinson Cancer Center $169,776 under the Cancer Research Manpower program (CFDA 93.398) for a two-year project (August 1, 2025–July 31, 2027) titled "Unraveling Myeloid-Mediated Mechanisms of Immunotherapy Resistance in Prostate Cancer Bone Metastases at Single-Cell Resolution." This project grant funds biomedical research training and investigator-initiated research focused on identifying and...
- Federal Project Grant Award Summary The National Cancer Institute awarded The Johns Hopkins University a $354,658 Project Grant under the Cancer Biology Research program (CFDA 93.396) effective August 1, 2025 through July 31, 2030. This award supports fundamental research investigating subclonal P27 (CDKN1B) loss as a driver of aggressive prostate cancer, with particular focus on understanding health disparities affecting Black or African American males who experience prostate cancer mortality...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded The Trustees of Columbia University in the City of New York a Project Grant of $531,825 under the Cancer Biology Research program (CFDA 93.396) effective August 1, 2025, with completion targeted for July 31, 2030. This research initiative focuses on understanding the molecular mechanisms of castration sensitivity in prostate epithelium, with the ultimate goal of improving therapeutic responses to androgen-deprivation therapy...
- Federal Grant Award Summary Mayo Clinic received a $484,803 Project Grant award from the National Cancer Institute under the Cancer Cause and Prevention Research program (CFDA 93.393) effective August 18, 2025, with completion scheduled for July 31, 2030. This research initiative focuses on elucidating glioma risk and improving patient outcomes by integrating germline and somatic genetics analysis. The project addresses critical gaps in understanding the functional relevance of 30 known germline...
- Federal Project Grant Award Summary Mayo Clinic received a $161,400 Project Grant award from the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research program (CFDA 93.394) for the period August 1, 2025 through July 31, 2027. The award supports research to develop and validate innovative ferroptosis-based therapeutic approaches targeting cholangiocarcinoma (CCA), a highly lethal malignancy of the liver and biliary tract with a five-year survival rate below 10%. The...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded Mayo Clinic a $415,000 Project Grant on May 14, 2026, under the Cancer Treatment Research program (CFDA 93.395) to support research on improving treatment sensitivity through spleen tyrosine kinase (SYK) inhibition using novel translational models of uveal melanoma (UM). This research addresses the critical clinical need to improve outcomes for uveal melanoma patients, as up to 50% develop metastatic disease with...
Mayo Clinic received a $307,381 Project Grant from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398), awarded July 1, 2026, with a completion date of June 30, 2031. This five-year research initiative focuses on exploiting SPOP (Speckle Type BTB/POZ Protein) mutations to develop novel synthetic lethality mechanisms for treating prostate cancer, particularly castration-resistant prostate cancer (CRPC). The research deliverables include three primary research objectives: determining how SPOP drives androgen receptor variant 7 (AR-V7) and androgen receptor pathway inhibitor (ARPI) resistance in prostate cancer cells (Aim 1); identifying mechanisms by which wild-type SPOP drives ataxia telangiectasia and Rad3-related (ATR) and poly-ADP-ribose polymerase (PARP) inhibitor resistance through FANCD2 and CAC1 pathways (Aim 2); and leveraging SPOP inhibitors to reverse ARPI, PARP inhibitor, and ATR inhibitor resistance (Aim 3). The project addresses a critical clinical need by providing research capabilities to understand treatment resistance mechanisms in the 85-90% of prostate cancer patients without SPOP mutations, with the goal of developing therapeutic strategies applicable across broader patient populations. By transforming SPOP mutations from a cancer-driving liability into a therapeutic vulnerability, the research aims to improve outcomes for patients with advanced prostate cancer who have exhausted conventional treatment options and face unfavorable median survivals of 11-13.6 months.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $307.4k | 5/14/26 |