Project Grant K08CA296933
- Federal Grant Award Summary Yale University received a $610,637 Project Grant from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395), awarded April 1, 2026, with completion targeted for March 31, 2031. The grant funds bioengineering research to develop an optimized drug delivery platform utilizing bioadhesive and non-adhesive biodegradable nanoparticles for locoregional treatment of advanced melanoma. The research will engineer nanoparticles with selective...
- Federal Grant Award Summary The National Cancer Institute awarded Yale University a $478,532 Project Grant under the Cancer Biology Research program (CFDA 93.396) effective September 1, 2025, through August 31, 2027. This research initiative will investigate the biological and clinical significance of spatial immune heterogeneity in non-small cell lung cancer (NSCLC), with particular focus on characterizing how the spatial distribution of tumor-infiltrating lymphocytes (TILs) and tertiary...
- Federal Grant Award Summary Yale University received a $150,104 Project Grant from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398), awarded January 16, 2026, with a completion date of August 31, 2028. This award supports research investigating the impact of aberrant 5-methylcytosine (M5C) messenger RNA (mRNA) modifications on translation initiation and cancer development. The research focuses on determining how dose-sensitive M5C modifications in...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded Yale University a $290,944 mentored clinical scientist research career development grant (Cancer Research Manpower program, CFDA 93.398) effective August 1, 2026, through July 31, 2031. This award supports a comprehensive training program enabling Dr. Benjamin Y. Lu to prepare for an independent academic research career as a physician-scientist while investigating immune checkpoint regulation in glioblastoma (GBM), the...
- Federal Grant Award Summary Yale University received a $672,371 Project Grant award from the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research Program (CFDA 93.394), effective September 1, 2025, through August 31, 2028. The grant funds development of ultra-sensitive mass spectrometry-based immunopeptidomics technology utilizing digital microfluidics to identify tumor-specific antigens (TSAs) for cancer immunotherapy applications. The project addresses current...
- Federal Project Grant Award Summary New York University School of Medicine received a $695,852 Project Grant award from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) effective May 1, 2026, through April 30, 2031. The project, "Investigating T Cell Circuits in the Lymphatic System During Melanoma Progression," delivers fundamental research services focused on understanding the mechanisms by which stem-like memory (TSL) CD8+ T cells are...
- Federal Grant Award Summary Yale University received a $167,771 Project Grant from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) awarded August 1, 2025, with completion targeted for July 31, 2027. The award supports research to elucidate the mechanisms of a novel human-specific immune checkpoint interaction between SIGLEC-7 and VSIG4 proteins. The research will utilize a humanized mouse platform (MISTRG6-A2) to develop in vivo models that investigate how...
- Federal Grant Award Summary The National Cancer Institute awarded The Johns Hopkins University a $510,431 Project Grant under the Cancer Biology Research program (CFDA 93.396) effective July 1, 2025 through June 30, 2030. This award supports fundamental research investigating the mechanisms of metastatic recurrence and therapeutic resistance in melanoma, with particular emphasis on understanding how aging influences tumor dormancy and the microenvironment. The research examines Wnt signaling...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a Project Grant of $257,472 to The Trustees of Columbia University in the City of New York, Health Sciences Division, effective September 6, 2025, through March 6, 2029, under the Cancer Research Manpower program (CFDA 93.398). This award supports research to dissect the impact of genomic variants on T cell anti-tumor activity, with the objective of enhancing T cell-based immunotherapies for melanoma and leukemia...
- Federal Project Grant Award Summary Yale University received a $192,564 Project Grant from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398), effective September 1, 2025 through August 31, 2028. The award supports the development of innovative dual-target Protease Targeted Chimera (PROTAC)-based protein degraders designed to overcome therapy resistance in metastatic castration-resistant prostate cancer (MCRPC). The research addresses lineage...
The National Cancer Institute awarded Yale University a $295,192 Project Grant under the Cancer Research Manpower program (CFDA 93.398) effective July 1, 2026 through June 30, 2031. This award supports Dr. Goran Micevic's career development as an independent investigator in basic and translational tumor immunology, epigenetics, and spatial transcriptomics. The research focuses on enhancing melanoma adoptive immunotherapy by identifying and epigenetically reprogramming a CD8+ T cell population marked by IL-7R expression that is critical for response to checkpoint therapy and shows promise as a cell-based therapeutic approach. The project delivers research products and services including isolation and characterization of IL-7R+ T cells from melanoma patient tumor and lymph node biorepository samples using spatial transcriptomics; identification of key epigenetic enzymes regulating T cell formation and maintenance through CRISPR-based approaches and epigenetic drug screening; and preclinical evaluation of epigenetically enhanced IL-7R+ T cells as a therapy for checkpoint-refractory melanoma using both immunocompetent and humanized mouse models. These research activities aim to advance understanding of immune mechanisms underlying melanoma treatment resistance and develop improved immunotherapy strategies for patients who fail to respond to current FDA-approved therapies, addressing a significant clinical need affecting approximately half of advanced melanoma patients.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $295.2k | 5/14/26 |