Project Grant R01CA304163
- Federal Project Grant Award Summary New York University School of Medicine received a $315,246 Project Grant award from the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398), effective August 1, 2025, through July 31, 2030. This five-year research initiative, titled "Breaking Cytokine Loops in Lung Adenocarcinoma," will deliver fundamental cancer research and scientific investigation focused on understanding immune resistance mechanisms in lung cancer...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a Project Grant of $257,472 to The Trustees of Columbia University in the City of New York, Health Sciences Division, effective September 6, 2025, through March 6, 2029, under the Cancer Research Manpower program (CFDA 93.398). This award supports research to dissect the impact of genomic variants on T cell anti-tumor activity, with the objective of enhancing T cell-based immunotherapies for melanoma and leukemia...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded Sloan-Kettering Institute for Cancer Research a $693,290 Project Grant effective May 1, 2026, through April 30, 2031, under the Cancer Detection and Diagnosis Research Program (CFDA 93.394). This research initiative focuses on identifying spatial tumor microenvironment (TME) signatures for risk stratification in primary melanoma through comprehensive multiplexed immunofluorescence (MIF) tissue imaging analysis of 450...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded the Regents of the University of Michigan a project grant totaling $660,808 under the Cancer Biology Research program (CFDA 93.396) to investigate the durability and function of tissue-resident memory T cells (TRM) in melanoma immunotherapy response and survival outcomes. The five-year research initiative, spanning from April 7, 2026 through March 31, 2031, will examine how TRM cells with high interferon-gamma...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded a $169,000 Project Grant under the Cancer Biology Research program (CFDA 93.396) to Icahn School of Medicine at Mount Sinai, effective August 1, 2025, through July 31, 2027. This research grant supports a two-year investigation into epigenetic regulation of melanoma-associated fibroblast plasticity, specifically examining how histone variant dysfunction affects the tumor microenvironment (TME). The principal...
- Federal Project Grant Summary New York University School of Medicine received a $217,600 Project Grant award from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398), effective September 26, 2025, with a completion date of March 31, 2029. The award supports biomedical research training and investigation into T cell acute lymphoblastic leukemia (T-ALL) infiltration of the central nervous system (CNS). The research project addresses a critical clinical...
- Federal Grant Award Summary The National Cancer Institute awarded Yale University a $295,192 Project Grant under the Cancer Research Manpower program (CFDA 93.398) effective July 1, 2026 through June 30, 2031. This award supports Dr. Goran Micevic's career development as an independent investigator in basic and translational tumor immunology, epigenetics, and spatial transcriptomics. The research focuses on enhancing melanoma adoptive immunotherapy by identifying and epigenetically reprogramming...
- Federal Project Grant Award Summary The National Cancer Institute awarded $452,540 to Sloan-Kettering Institute for Cancer Research under the Cancer Biology Research program (CFDA 93.396) for a project grant spanning May 1, 2026 through April 30, 2028. The funded research addresses innate and adaptive determinants of cytokine release syndrome (CRS) in chimeric antigen receptor (CAR) T cell therapies for hematologic malignancies. The project investigates the molecular mechanisms underlying CRS, a...
- Federal Grant Award Summary The National Cancer Institute awarded Weill Medical College of Cornell University a $694,133 Project Grant under the Cancer Biology Research program (CFDA 93.396) on May 14, 2026, with completion targeted for April 30, 2031. This research initiative focuses on defining the role of sympathetic nervous system axons in controlling melanoma tumor progression, with particular emphasis on how these neuronal projections inhibit cancer growth through interactions with...
- Federal Grant Award Summary The National Cancer Institute awarded The Johns Hopkins University a $510,431 Project Grant under the Cancer Biology Research program (CFDA 93.396) effective July 1, 2025 through June 30, 2030. This award supports fundamental research investigating the mechanisms of metastatic recurrence and therapeutic resistance in melanoma, with particular emphasis on understanding how aging influences tumor dormancy and the microenvironment. The research examines Wnt signaling...
New York University School of Medicine received a $695,852 Project Grant award from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) effective May 1, 2026, through April 30, 2031. The project, "Investigating T Cell Circuits in the Lymphatic System During Melanoma Progression," delivers fundamental research services focused on understanding the mechanisms by which stem-like memory (TSL) CD8+ T cells are maintained and function within tumor-draining lymph nodes (TDLNs) during melanoma disease progression and immunotherapy treatment. The research leverages specialized expertise in lymphatic system biology combined with innovative tools to track and manipulate T cell populations in melanoma contexts, with the objective of generating mechanistic insights that can inform future clinical management strategies for the lymphatic basin in neoadjuvant immunotherapy settings. The project addresses a critical gap in understanding how anti-tumor immune surveillance is sustained in TDLNs and how standard-of-care clinical therapies impact this process. The research specifically examines the differential abundance and functionality of TSL cells in situ, with the underlying hypothesis that maintaining TSL populations in the draining lymphatic basin will support systemic immune surveillance in melanoma patients. Findings from this five-year investigation are intended to guide clinical strategies for optimizing immune checkpoint blockade efficacy in high-risk, lymph node-positive melanoma patients by better understanding the role of lymphatic basin immune compartments in immunotherapy response.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $695.9k | 4/29/26 |