Project Grant K08AR081986
- This Project Grant award, funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research Program (CFDA 93.846), provides $412,756 to The University of Texas Southwestern Medical Center (UT Southwestern) to conduct research on the mechanisms regulating bone healing and angiogenesis in osteonecrosis. The research aims to fully characterize the process of stem cell differentiation and revascularization in...
- This $219,609 project grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) is aimed at developing a method to assess mechanical failure of bone matrix using in vitro cell culture. The primary goal is to overcome the current challenge of requiring whole mouse bone specimens to detect changes in bone matrix mechanical properties, by using micropillars generated from...
- This federal Project Grant award of $685,866.00 was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846). The goal of this 5-year project is to leverage context-specific expression quantitative trait loci (eQTLs) to identify potential causal genes underlying genome-wide association study (GWAS) findings related to bone mineral density (BMD) and...
- This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to identify myeloid progenitors that maintain cortical bone mass with age and characterize factors that promote coupling within cortical bone. The $375,100 award, active from Sep 20, 2024 to Aug 31, 2026, supports research at the University of Minnesota to address the significant impact of...
- This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $386,481 to the University of Connecticut Health Center to research cellular therapy approaches for treating osteogenesis imperfecta (OI), a genetic bone disorder. The project aims to evaluate different stem/progenitor cell populations, determine the mechanisms by which irradiation improves...
- This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846), will provide $175,948 to The General Hospital Corporation (doing business as Massachusetts General Hospital) to investigate the molecular mechanisms underlying the synergistic effects of mechanical loading and hormonal signaling in bone cells. The research aims to identify how focal...
- This $146,070 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to investigate how the accumulation of senescent cells and their secretory phenotypes impact osteocyte mechanobiology in a 3D bone-mimicking microenvironment. The goals are to: (1) acquire experimental skills and career training to expand the researcher's program into cellular aging/senescence and molecular biology; (2) investigate how local vs. systemic senescent cells and...
- This Project Grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), provides $688,634.00 in funding to The Hospital For Special Surgery Fund, Inc. (dba HSS Foundation) from December 1, 2024 to November 30, 2029. The award supports research to investigate the mechanisms by which the constitutive type-I interferon (IFN-I) response suppresses osteoblastogenesis and bone formation, especially in the context of inflammatory conditions like rheumatoid...
- This $465,663 Project Grant was awarded on May 6, 2025 by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The grant supports research to optimize the bone surface targeting of therapeutic antibodies for the treatment of osteoporosis, a common bone disease affecting 10 million U.S. adults. The project aims to increase the local concentration and efficacy of osteoporosis...
- This $159,594 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research to identify new therapeutic targets for osteogenesis imperfecta (OI), a rare genetic bone disorder. The award recipient, the Research Foundation of the City University of New York (RFCUNY), will investigate the intracellular signaling and extracellular matrix mechanisms...
This Project Grant award of $170,931 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) will support a 5-year research and career development program for Dr. Diana Athonvarangkul at Yale University. The research aims to elucidate the mechanisms regulating osteocytic osteolysis, a process by which the most abundant bone cell type, the osteocyte, remodels bone. Specifically, the project will investigate how osteoclastic bone resorption influences a phenotypic switch in osteocytes to upregulate osteoclastogenic factors and promote bone resorption. This work is expected to provide critical insights into the coordination between osteoclasts and osteocytes during accelerated bone turnover, with potential implications for disorders like osteoporosis.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $170.9k | 8/4/25 |