Project Grant K08AI199235
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $847,000 in Project Grant funding to The University of Kentucky Research Foundation on July 15, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The research, scheduled for completion by June 30, 2027, focuses on identifying the protective roles of CD180 and nucleotide oligomerization domain 1 (NOD1)—two pathogen-associated molecular pattern...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The University of Kentucky Research Foundation a Project Grant totaling $1,731,364 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on August 29, 2025, with a completion date of July 31, 2029. This biomedical research grant supports investigator-initiated scientific research examining the mechanisms by which microglial interferon-gamma (IFN-γ) production functions as a...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The University of Kentucky Research Foundation a Project Grant totaling $423,500 under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective July 1, 2025, through June 30, 2027. This research project investigates the functional roles of chlamydial polymorphic membrane proteins (PMPs), specifically PMPI, during the infectious cycle of Chlamydia trachomatis. The...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Virginia $795,990 under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct a five-year research project spanning April 23, 2026 through March 31, 2031. The project, titled "Targeting Resistance at Its Source: Identifying Superspreaders of Antimicrobial Resistance Genes in Hospital Ecosystems," delivers advanced research services...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The University of Kentucky Research Foundation a $184,592 Project Grant on May 22, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate microbial contamination and persistence in flood-affected building materials. The research will be conducted in Lexington, Kentucky, with a completion date of April 30, 2028. The project combines field-based floodwater...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Health Research, Inc.'s Wadsworth Center a $1.38M Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop therapeutic products and conduct research on mycobacteriophage lysin (LYSB) as a treatment for Mycobacterium abscessus (MAB) infections. The project, initiated July 18, 2025, and extending through June 30, 2030, focuses on translating preclinical...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Virginia a $1,201,716 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) on August 6, 2025, for research titled "Chemical Grammar of Accumulation in Drug Resistant Acinetobacter baumannii with Subcellular Resolution." The project, with performance in Charlottesville, Virginia, and completion scheduled for July 31, 2030, will develop...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The University of Kentucky Research Foundation a $420,063 Project Grant on February 18, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to fund research investigating the molecular mechanisms controlling bacteriophage lysis in Borrelia burgdorferi, the spirochete responsible for Lyme disease. The Stevenson Lab will identify and functionally characterize...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Illinois a $585,539 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective September 4, 2025, with a completion date of August 31, 2030. This research initiative investigates Acinetobacter baumannii carbon metabolism during intermicrobial competition within the human gastrointestinal tract to develop strategies for preventing...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Pittsburgh a $799,572 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) for the period April 1, 2026 through March 31, 2031. The project, titled "Time Resolved Structural Analyses of B-Lactam/B-Lactam Inhibitor Binding to AmpC," addresses critical gaps in understanding antimicrobial resistance mechanisms by investigating the...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded The University of Kentucky Research Foundation a $181,103 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) for a three-year research initiative spanning June 1, 2026, through May 31, 2029. This research project delivers mechanistic and transcriptomic modeling studies comparing the therapeutic efficacy of aztreonam/avibactam (ATM/AVI) versus aztreonam plus ceftazidime/avibactam (ATM+CZA) in treating multidrug-resistant Stenotrophomonas maltophilia (SM) infections. The research addresses a critical clinical gap where current susceptibility testing fails to reliably predict bacterial killing, risking treatment failure and resistance emergence in patients with severe SM infections. The project produces three primary research products: (1) comparative bacterial killing and resistance prevention data from hollow-fiber infection models simulating human drug exposure; (2) in vivo efficacy assessments using neutropenic mouse lung models, measuring bacterial burden reduction, biofilm effects, immune responses, and drug distribution; and (3) gene expression analysis using RNA sequencing to identify molecular mechanisms of bacterial response to each antibiotic regimen. These deliverables collectively establish evidence-based guidance for optimized SM treatment selection and contribute to advancing precision infectious disease therapeutics through isolate- and host-specific therapeutic data.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $181.1k | 5/28/26 |