Project Grant R01AI191591
- The University of Illinois received a $582,350 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on "Microbiota-Mediated Colonization Resistance to Acinetobacter Baumannii." The research aims to identify key gut resident microbes that can synergize with a complex microbiota to prevent colonization by the multidrug-resistant pathogen Acinetobacter...
- The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), awarded a $585,539 Project Grant under the Allergy and Infectious Diseases Research Program (CFDA 93.855) to the University of Illinois in Chicago. The grant supports research to understand how the pathogen Acinetobacter baumannii, a major public health threat due to its drug resistance, colonizes and persists in the human gut microbiome. The project aims to investigate A....
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $254,478 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The University of Texas Southwestern Medical Center to identify mechanisms of resistance to pathogen-specific antibacterial antisense compounds and develop strategies to circumvent them. The project aims to determine the resistance mechanisms for lead peptide-phosphorodiamidate morpholino oligomers (PPMOs) against...
- The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), awarded a $490,093 Project Grant to the University of Maryland, College Park on April 10, 2025. The funding supports the development of a rapid, inexpensive microfluidic technology to isolate bacteria directly from whole blood, identify pathogens, and evaluate their antibiotic response within 75 minutes. This will enable clinicians to move...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a Project Grant of $109,476 under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855) to the University of Wisconsin - Madison. The grant, titled "Understanding the Molecular Rules of a Bacterial Multidrug Efflux Transporter", aims to measure the function of 7,760 single mutations in the NorA multidrug efflux pump to better understand the mechanisms of antimicrobial resistance. The...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $125,973 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Regents of the University of Michigan. The grant, awarded on February 3, 2025, aims to identify patient and bacterial factors associated with the emergence and spread of resistance to two novel beta-lactam/beta-lactamase inhibitor antibiotic therapies: meropenem-vaborbactam and imipenem-relebactam. The researchers...
- This $481,250 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855). The grant will fund the development of new antimicrobial small molecule compounds that recruit the immune system to target bacteria. Key activities include the biochemical, biophysical, and cell biology characterization of these chimeric molecules formed by joining bacterial binding agents with...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $195,625 Project Grant under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855) to the University of Colorado Boulder. The grant supports research to structurally and functionally characterize phosphoethanolamine (PEtN) transferases, enzymes responsible for conferring resistance to cationic antimicrobial peptides (CAMPs) and the antibiotic colistin in multidrug-resistant Gram-negative...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $3,047,991 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Rector & Visitors of the University of Virginia. The grant, awarded on September 12, 2025, will fund research to investigate the molecular basis for paired receptor signaling in antiviral natural killer (NK) cells during murine cytomegalovirus (MCMV) infection. The research aims to delineate how NK cell receptor...
- This Project Grant award of $624,267 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) will fund research at Texas A&M University System Health Science Center (TAMU HSC) to develop methods for accurately quantifying the accumulation of small molecule compounds in Gram-negative bacteria like Acinetobacter baumannii. The research aims to provide insights into the physicochemical properties that enable compound entry into...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $1,201,716 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Rector & Visitors of the University of Virginia (UVA). The grant, effective August 6, 2025 through July 31, 2030, aims to develop and apply innovative high-throughput screening platforms to measure the accumulation of small molecules in the multidrug-resistant pathogen Acinetobacter baumannii (A. baumannii). This research seeks to identify the chemical properties that facilitate molecular entry and accumulation within these bacterial cells, as well as discover new outer membrane disruptors that can enhance the efficacy of existing antibiotics against drug-resistant A. baumannii strains. By integrating these findings with advanced machine learning algorithms, the project aims to establish a comprehensive framework for predicting molecular permeability in A. baumannii to support the development of more effective antimicrobial treatments.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.2m | 8/12/25 |