Project Grant R01AI181567
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $847,000 Project Grant through the Allergy and Infectious Diseases Research program (CFDA 93.855) to The University of Kentucky Research Foundation. The purpose of this 2.5-year award, beginning July 2025, is to investigate the protective roles of the CD180 and NOD1 molecules in the immune response against cerebral Toxoplasma gondii infection. The research aims to better understand how these pathogen-associated molecular...
- The Project Grant award of $135,315.00, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), supports research to investigate the impact of Toxoplasma gondii infection on the regulatory T cell (Treg) population in mice. The study aims to enhance understanding of the rebuilding process and long-term effects of the Treg collapse induced by acute T. gondii infection. The research will...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $454,036 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of California, Irvine (UCI). The grant, titled "Microglial Immunity in Toxoplasmic Encephalitis", will support research to determine the role of brain-resident microglia cells in immune defense against the Toxoplasma gondii parasite, which commonly infects HIV/AIDS patients and can lead to...
- This federal Project Grant award of $563,513.00 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855). The funding supports research at Arizona State University to investigate the patterning, growth, and maturation of the cortical microtubules in Toxoplasma, a unicellular parasite that causes diseases such as toxoplasmosis. The research aims to explore the initiation of patterning...
- This Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $2,456,732 to support research on Toxoplasma gondii infection in people living with HIV/AIDS (PLWHA). The research aims to understand the mechanisms behind the parasite's ability to cause latent infections in the central nervous system and reactivate, leading to toxoplasma encephalitis - a significant cause of...
- This Project Grant award of $427,604 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to elucidate the molecular mechanisms of conoid extrusion in the pathogen Toxoplasma gondii. The goal is to reconstitute the core elements of the parasite's apical complex, including actin, myosin, and a formin, in vitro to gain a mechanistic understanding of how the conoid structure is extruded...
- This Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA Program 93.855 - Allergy and Infectious Diseases Research, will support research to investigate the genetic mechanisms that determine host susceptibility to low virulence strains of the Toxoplasma gondii parasite in mice. The $269,054 award, effective November 8, 2024 through October 31, 2026, will enable researchers at the University of California, Merced to leverage the...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $817,730 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Vermont & State Agricultural College. The grant, awarded on July 9, 2025, supports the development of new tools to study how the Toxoplasma gondii parasite delivers its "effector" proteins into host cells during the invasion process. This research aims to understand the mechanisms by which T....
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $435,875 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of California, Merced. The grant, titled "Interrogating NFKBID Dependent Humoral Immunity to Toxoplasma gondii", seeks to understand the mechanisms by which the transcriptional regulator IKBNS (encoded by NFKBID) mediates protective immunity against the parasitic infection Toxoplasma gondii. The...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $107,995 to investigate the role of T cells in promoting post-acute memory deficits after COVID-19 infection in mice. The funding supports the use of a recently developed mouse model to study how systemic inflammation promotes the recruitment of antigen-specific T cells to the central nervous system after SARS-CoV-2 infection, and how these T...
This federal Project Grant award of $700,000.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to understand the role of microglia, a type of brain-resident immune cell, in coordinating both innate and T cell-mediated immunity to prevent reactivation of cerebral toxoplasmosis infection in AIDS patients. The research aims to 1) define the importance of microglial IFN-γ production for recruiting and activating innate immune cells like monocytes, NK cells, and ILC1 cells to suppress Toxoplasma gondii growth in the brain, and 2) reveal how microglial IFN-γ coordinates the recruitment and activation of CD8+ T cells to areas of cerebral infection, enhancing MHC class I antigen presentation to prevent toxoplasmic encephalitis. This multi-year research project, with an award period from August 29, 2025 to July 31, 2029, is being conducted by the University of Kentucky Research Foundation.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $700.0k | 8/29/25 |