Project Grant R01AI192538
- The University of Illinois received a $582,350 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on "Microbiota-Mediated Colonization Resistance to Acinetobacter Baumannii." The research aims to identify key gut resident microbes that can synergize with a complex microbiota to prevent colonization by the multidrug-resistant pathogen Acinetobacter...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $1,201,716 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Rector & Visitors of the University of Virginia (UVA). The grant, effective August 6, 2025 through July 31, 2030, aims to develop and apply innovative high-throughput screening platforms to measure the accumulation of small molecules in the multidrug-resistant pathogen Acinetobacter baumannii (A. baumannii)....
- The University of Illinois received a $154,052 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant, awarded on August 5, 2025, aims to understand how arginine availability in the gut modulates the pathogenesis of the enteric pathogen Salmonella enterica serovar Typhimurium (STM). Key objectives include: 1) examining the direct utilization of arginine by STM, gut microbiota, and...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $195,625 Project Grant under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855) to the University of Colorado Boulder. The grant supports research to structurally and functionally characterize phosphoethanolamine (PEtN) transferases, enzymes responsible for conferring resistance to cationic antimicrobial peptides (CAMPs) and the antibiotic colistin in multidrug-resistant Gram-negative...
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $569,210 to the University of Colorado Boulder to conduct research on the "Mechanisms of Lipid A Modification Impacting Antimicrobial Resistance". The key focus is on understanding how certain gram-negative pathogens modify their lipid A structures to develop resistance against cationic antimicrobial...
- This $475,036 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) will fund research to explore synergistic combinations of aminoglycoside antibiotics against multidrug-resistant (MDR) gram-negative bacteria. The project aims to: 1) examine dual-aminoglycoside combinations against MDR pathogens like Enterobacter cloacae, E. coli, and Klebsiella pneumoniae, 2) solve the structural details of how multiple...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $254,478 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The University of Texas Southwestern Medical Center to identify mechanisms of resistance to pathogen-specific antibacterial antisense compounds and develop strategies to circumvent them. The project aims to determine the resistance mechanisms for lead peptide-phosphorodiamidate morpholino oligomers (PPMOs) against...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $139,770 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Oklahoma Health Sciences Center. The grant is for a project titled "Human Gut Bacteroidales Defense Mechanisms Against Emerging Antibacterial Toxins". The project aims to study a family of antibacterial, pore-forming toxins produced by members of the bacterial order Bacteroidales that are...
- The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), awarded a $490,093 Project Grant to the University of Maryland, College Park on April 10, 2025. The funding supports the development of a rapid, inexpensive microfluidic technology to isolate bacteria directly from whole blood, identify pathogens, and evaluate their antibiotic response within 75 minutes. This will enable clinicians to move...
- This $392,634 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports the development of a novel nanoimmunotherapeutic approach to combat multidrug-resistant (MDR) bacterial infections. The project aims to design, fabricate, and optimize a red blood cell membrane-coated, hemoglobin-encapsulating nanoparticle (RHNP) that can sensitize bacteria to host oxidant killing while...
The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), awarded a $585,539 Project Grant under the Allergy and Infectious Diseases Research Program (CFDA 93.855) to the University of Illinois in Chicago. The grant supports research to understand how the pathogen Acinetobacter baumannii, a major public health threat due to its drug resistance, colonizes and persists in the human gut microbiome. The project aims to investigate A. baumannii's carbon metabolism strategies, particularly its ability to utilize the nutrient ornithine, that enable it to outcompete the resident gut microbiota and asymptomatically colonize the gastrointestinal tract. The research conducted under this 5-year award from September 2025 to August 2030 will provide insights into A. baumannii pathogenesis and inform new approaches to prevent its spread in healthcare settings.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $585.5k | 9/4/25 |