Project Grant K08AI193408
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Methodist Hospital Research Institute a $2.47 million Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective April 1, 2026, through March 31, 2030. This research initiative focuses on deciphering the activation mechanisms and immune functions of gasdermin C (GSDMC), a protein family member critical to innate immune responses and...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Leland Stanford Junior University a Project Grant of $434,090 under the Allergy and Infectious Diseases Research program (CFDA 93.855) for research commencing April 1, 2026, and concluding March 31, 2028. This award funds research investigating the role of low-abundance commensal microbial species in conferring colonization resistance against Clostridioides difficile infection (CDI), a...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Methodist Hospital Research Institute a Project Grant of $444,125 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on August 8, 2025, with a completion date of July 31, 2027. This research project will characterize a previously unknown intercellular signaling pathway in Group B Streptococcus (GBS) and determine its contribution to bacterial pathogenesis. Specifically,...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Methodist Hospital Research Institute a $300,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) on August 7, 2025, for completion by July 31, 2026. This award supports investigative research on lactate dehydrogenase A (LDHA)-dependent T-cell effector programs in heart transplantation. The research will produce scientific knowledge and methodological...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $3.52 million to the Sloan-Kettering Institute for Cancer Research under the Allergy and Infectious Diseases Research program (CFDA 93.855) on March 1, 2026, for a four-year project period concluding February 28, 2030. The award funds development of computational microbiome management tools to predict, prevent, and mitigate gut-borne bloodstream infections in immunocompromised patients. The...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Leland Stanford Junior University a $423,500 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) for the period April 1, 2026, through March 31, 2028. This research initiative focuses on elucidating the effects of oxygen and bile acid processing on the small intestinal microbiome and colonization resistance. The project will generate research...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a Project Grant of $132,677 to Icahn School of Medicine at Mount Sinai on August 5, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award supports a two-year research initiative (concluding July 31, 2027) that maps inflammatory bowel disease (IBD) genetic variants to their functional consequences in human macrophages. The project employs large-scale CRISPRi...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Johns Hopkins University a Project Grant of $195,640 (awarded September 17, 2025) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support a five-year research career development initiative examining the vaginal microbiome and bacterial vaginosis (BV) treatment outcomes. The research will identify subpopulations that demonstrate enhanced therapeutic response to...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Methodist Hospital Research Institute a $491,663 Project Grant, obligated on February 3, 2026, through the Allergy and Infectious Diseases Research program (CFDA 93.855) to support research titled "The Epigenetic Regulation of Alloimmune Stem-Like CD4+ T Cells." The five-year project, concluding January 31, 2031, will deliver fundamental biomedical research investigating...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a Project Grant of $222,085 to The Regents of the University of California, San Francisco on October 24, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award supports a research project titled "Unraveling Skin Microbiota-Immune Interactions That Drive Early Life Commensal Tolerance," with a completion date of November 6, 2026. The research will be...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Methodist Hospital Research Institute a $184,030 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) on June 1, 2026, with completion anticipated by May 31, 2031. This K08 career development award supports a five-year research and training initiative led by Dr. Fan to advance expertise in microbiome manipulation within immunotherapy-related enterocolitis (IMEC). The research addresses the critical issue of antibiotic-induced dysbiosis in cancer patients undergoing immune checkpoint inhibitor therapy, investigating how specific bacterial species and carbohydrate-degrading enzyme expression influence clinical outcomes. Key deliverables include characterization of the role of Bacteroides xylanisolvens and vancomycin-resistant Enterococcus faecium in IMEC pathogenesis, mechanistic studies of polysaccharide utilization loci gene expression, and evaluation of fecal microbiota transplantation (FMT) as a therapeutic intervention to restore protective microbial communities. The award supports both basic science investigations into host-microbiome interactions during immunotherapy and translational research translating laboratory findings into clinical applications for improving patient outcomes in cancer immunotherapy-related gastrointestinal complications. As a career development mechanism, the grant incorporates structured research and training components designed to establish Dr. Fan as an independent physician-scientist with specialized knowledge in microbiome-based therapeutic strategies for immune-mediated enterocolitis.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $184.0k | 6/1/26 |