Project Grant K23AI193080
- The federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), part of the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), will provide $511,763 to Seattle University to conduct activity-based protein profiling of the vaginal microbiome. The goal is to understand how enzymes related to glycogen degradation and microbial proteases are associated with vaginal community composition and bacterial vaginosis. The 3-year project,...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $300,000 in funding to Topaz Biosciences, Inc. to discover and optimize novel endolysins that can selectively target Gardnerella vaginalis, the primary bacterial species associated with bacterial vaginosis (BV). The goal is to develop improved endolysins that are more active, thermostable, and pH tolerant than...
- This Project Grant award, valued at $126,460 and provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to identify ecological drivers of dysbiosis in the female reproductive tract. The research will use genetically tractable uropathogenic E. coli and specialized animal and tissue culture models to determine how host cell metabolism controls vaginal community composition and perpetuates...
- This $310,136 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) is funding the development of an intravaginal ring that can sustain high vaginal levels of lactic acid to treat and prevent bacterial vaginosis (BV). The funding supports research by Mucommune LLC, a biopharmaceutical company in Durham, North Carolina, to directly measure the rate of lactic acid loss from the vagina and then engineer a...
- This $1,025,000 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855) supports the development of "MM-009", an intravaginal ring designed to continuously release lactic acid over a 30-day period. The goal is to treat and prevent bacterial vaginosis, a vaginal condition affecting millions of women in the U.S. The funding supports the IND-enabling development of...
- This federal Project Grant award of $243,750 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to investigate how the bacterium Gardnerella promotes the pathogenesis of Neisseria gonorrhoeae, the causative agent of the sexually-transmitted infection gonorrhea. The key objectives are to determine the mechanisms by which Gardnerella virulence factors, including the cytolytic toxin...
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), is focused on elucidating the role of Akkermansia muciniphila in Group B Streptococcal (GBS) vaginal colonization and ascending infection. The $148,568 award will support research to investigate the specific mechanisms by which A. muciniphila promotes GBS interaction with human vaginal epithelial cells, potentially...
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $404,273 to Virginia Commonwealth University (VCU) to conduct research on the effects of the bacteria Sneathia vaginalis on the amnion, which could play a role in preterm birth and premature rupture of membranes. The key goals of the project are to characterize the damage Sneathia vaginalis causes to the...
- This $402,731 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), authorized under the Allergy and Infectious Diseases Research program (CFDA 93.855), will fund a program to increase the number of next-generation physician-scientists who can apply knowledge of microbiology, immunology, and research techniques to improve reproductive, maternal, and child health. The award will support 4 physician-scientists in pediatrics or obstetrics/gynecology residency...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $529,498 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Siolta Therapeutics Inc. for the development of a multispecies live biotherapeutic product (LBP) called STMC-105. The goal of this project is to create an FDA-approved therapy for the prevention of recurrent bacterial vaginosis (RBV) in women by enhancing the colonization of protective Lactobacillus bacteria and reducing...
This $195,640 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports a 5-year research program at Johns Hopkins University to study the vaginal microbiome and its contributions to bacterial vaginosis (BV). The research aims to evaluate mechanisms for treatment failure and identify subpopulations that may respond better to the antibiotic clindamycin versus the more commonly prescribed metronidazole. The program builds on the principal investigator's previous clinical experience in recurrent vaginitis and integrates new expertise in areas like the vaginal microbiome, 'omics analysis, and bioinformatics to transition the researcher to independence as a physician scientist.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $195.6k | 9/17/25 |