Project Grant R01AI190307
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Methodist Hospital Research Institute a Project Grant of $444,125 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on August 8, 2025, with a completion date of July 31, 2027. This research project will characterize a previously unknown intercellular signaling pathway in Group B Streptococcus (GBS) and determine its contribution to bacterial pathogenesis. Specifically,...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Methodist Hospital Research Institute a $300,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) on August 7, 2025, for completion by July 31, 2026. This award supports investigative research on lactate dehydrogenase A (LDHA)-dependent T-cell effector programs in heart transplantation. The research will produce scientific knowledge and methodological...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Methodist Hospital Research Institute a $2.71 million Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) on August 12, 2025, for research extending through May 31, 2029. This award supports the development and characterization of a novel generation of self-adjuvanted messenger RNA (mRNA) vaccines targeting Mycobacterium tuberculosis (MTB), the causative...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Methodist Hospital Research Institute a Project Grant of $491,663 under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective February 3, 2026, through January 31, 2031. This research initiative investigates the epigenetic regulation of stem-like CD4+ T cells in alloimmune responses, with the goal of understanding mechanisms that sustain transplant...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $899,850 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Whitehead Institute for Biomedical Research, effective February 20, 2026, through January 31, 2031. This award supports fundamental research aimed at elucidating the molecular mechanisms by which apicomplexan parasites recognize and invade host cells—a critical process for parasite survival...
- Federal Project Grant Award Summary Harvard Medical School received a $207,166 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective July 15, 2025, with completion targeted for February 29, 2028. This award supports investigator-initiated biomedical research aimed at elucidating the molecular mechanisms underlying the activation and regulation of gasdermin D (GSDMD), a...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $566,875 to the La Jolla Institute for Immunology under the Allergy and Infectious Diseases Research program (CFDA 93.855) on February 18, 2026, with a completion date of January 31, 2028. Under this Project Grant, the institute will conduct research to de-orphanize a novel G-protein coupled receptor (GPCR) expressed by tissue-resident memory T cells (TRM cells). The research objective...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Applied Biomedical Science Institute a Project Grant of $976,318 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on April 6, 2026, with a project completion date of March 31, 2031. The award funds research to elucidate the molecular mechanisms underlying the cow immune system's production of ultralong complementarity-determining region H3 (CDR H3) antibodies—a unique...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $460,625 to The Feinstein Institutes For Medical Research on February 10, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support investigator-initiated biomedical research. The project, titled "Maturation and Maintenance of the Germinal Center Niche," will be conducted through January 31, 2028, at the awardee's Manhasset, New York facility....
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $794,183 to the Beckman Research Institute of the City of Hope on April 8, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). This five-year project, extending through March 31, 2031, supports investigator-initiated biomedical research into the role and regulation of methylarginine effector Tudor Domain-Containing Protein 3 (TDRD3) in T cell immunity. The...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Methodist Hospital Research Institute a $2.47 million Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective April 1, 2026, through March 31, 2030. This award supports fundamental biomedical research aimed at deciphering the activation mechanisms and immune functions of gasdermin C (GSDMC), a protein family member critical to innate immunity and inflammatory responses. The research project focuses on identifying and characterizing the protease responsible for cleaving and activating GSDMC, as well as elucidating the unique molecular properties, cellular localization patterns, and in vivo immune regulatory functions of activated GSDMC that distinguish it from other gasdermin family members. The deliverables include scientific findings on GSDMC's role in amplifying type-2 immune responses through mechanisms independent of pyroptosis and plasma membrane pore formation, investigation of subcellular organelle localization patterns of the GSDMC N-terminus, and comprehensive mechanistic understanding of how this protein family member regulates immune responses in animal models. The research is being conducted at the awardee's Houston, Texas facility and will contribute to the broader scientific knowledge base supporting development of therapeutic interventions targeting infectious diseases and immunologic disorders.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.5m | 3/27/26 |