Project Grant K08AI182490

Award Date 8/19/24
Completion Date 1/10/25
Dollars Obligated $174K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Connecticut, USA
Similar Awards
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $555,774.00 to the University of Alabama at Birmingham (UAB) over a 5-year period starting November 19, 2024. The award supports research to investigate the role of the aryl hydrocarbon receptor (AhR) pathway in regulating the development of T-bet+ B cells, which are implicated in the pathogenesis of systemic lupus...
This federal Project Grant award, valued at $715,957 and awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under CFDA Program 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research, supports research to elucidate the molecular mechanisms by which interferon cytokines promote the differentiation and expansion of T peripheral helper (Tph) cells in systemic lupus erythematosus (SLE) patients. The award, with a project period from March 2025 to...
This $793,093 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) aims to define the regulatory landscape of systemic lupus erythematosus (SLE) and its cardiovascular disease (CVD) comorbidity. The grantee, Oklahoma Medical Research Foundation, will conduct systematic, high-throughput studies in macrophages derived from induced pluripotent stem cells to identify genetic variants that disrupt regulatory...
The federal Project Grant award R21AI183127, totaling $423,500.00, was awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The primary goal of this 2-year award to Loyola University of Chicago is to develop novel antibodies that specifically target autoreactive B cells as a potential therapeutic approach for treating systemic lupus erythematosus (SLE), particularly in African American patients...
The University of Michigan received a $1,540,008 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) on June 5, 2025. The grant, titled "Integrated Program for Cutaneous Immune-Stromal Interactions in SLE (IPCISS)", supports interdisciplinary translational research on systemic lupus erythematosus (SLE) and cutaneous lupus erythematosus (CLE). The program aims to: 1) develop knowledge of the...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Program (CFDA 93.855), provides $256,808 to the University of Washington to investigate the role of dysregulated mRNA splicing in systemic lupus erythematosus (SLE). The goal is to better define the molecular mechanisms that cause and perpetuate SLE by examining altered protein structures and neoepitopes in lupus neutrophils. The research...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $709,019 to the Benaroya Research Institute at Virginia Mason in Seattle, WA to conduct research on the role of the FOXP3 isoform in regulating autoantibody production and the development of systemic lupus erythematosus (SLE). The key objectives are to: 1) determine how the FOXP3 exon 2 isoform impacts germinal...
This Project Grant award of $413,860, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), will support research to investigate the interactions between non-tuberculous mycobacteria (NTM) infections, specifically Mycobacterium abscessus (MAB), and the onset/progression of systemic lupus erythematosus (SLE). The research will utilize preclinical mouse models and ex vivo models with fetal...
This federal Project Grant award of $558,045.00 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) program. The grant aims to investigate how the enzyme protein phosphatase 2A (PP2A) regulates immune cell function and metabolism in the context of systemic lupus erythematosus (SLE). Key objectives include determining how PP2A controls enzymes involved in glycolysis and the pentose phosphate pathway,...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will support research to investigate the potential impairment of hematopoietic stem cells (HSCs) as a source of hematological abnormalities and inflammation in systemic autoimmune diseases such as systemic lupus erythematosus (SLE). The $216,113 award to New York University will fund a 2-year...

This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports a 5-year career development program for a dermatologist and physician-scientist to study the role of retroelements in systemic lupus erythematosus (SLE). The $173,556 award will enable the researcher to delineate gene and retroelement expression patterns, inflammatory cytokine levels, and retroelement-specific autoreactive CD4+ T cells in SLE patients. The goal is to evaluate a previously undescribed pathway to autoimmunity with future therapeutic potential. This research program is being conducted at Yale University and is supervised by a leading expert in the complex interplay between viruses, innate immunity, and adaptive immunity.

Generated 8/5/25, 4:37 AM