This $256,808 Project Grant award was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Washington. The goal of the research is to better define the molecular mechanisms that cause and perpetuate systemic lupus erythematosus (SLE). The project aims to expand analysis of altered mRNA splicing in SLE neutrophils, understand its relation to disease characteristics, and explore...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $702,511 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Chicago. The grant, awarded on August 15, 2024, will support research using artificial intelligence to study the progression of lupus nephritis, a severe manifestation of systemic lupus erythematosus. The project aims to bridge the understanding of lupus nephritis progression between human and murine...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $173,556.00 to Yale University to support research on the role of retroelements in the pathogenesis of systemic lupus erythematosus (SLE). The key objectives are to: (1) delineate gene and retroelement expression patterns as well as inflammatory cytokine levels in the peripheral blood and skin of SLE patients; (2) identify and phenotype...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $715,957 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to Northwestern University to conduct research on the mechanisms underlying interferon-induced T peripheral helper (Tph) cell differentiation in systemic lupus erythematosus (SLE). The project, which runs from March 2025 to February 2030, will apply cutting-edge biochemical, epigenetic, and genetic approaches to...
This $375,100 federal Project Grant award was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The grant funds a study to investigate the interplay between nucleic-acid-dependent phase separation and immune responses against cyclic GMP-AMP synthase (cGAS) in systemic lupus erythematosus (SLE). The research aims to determine how changes in the biophysical...
This $793,093 federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) will support research by the Oklahoma Medical Research Foundation to study the regulatory landscape of systemic lupus erythematosus (SLE) and its cardiovascular disease (CVD) comorbidities. The research aims to identify causal genetic variants, target genes, and cell types involved in SLE pathogenesis, with a focus on the role of...
This $216,113 federal Project Grant award, issued by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research to investigate the mechanism of hematological abnormalities in systemic autoimmunity. The research aims to characterize impairment in hematopoietic stem cells (HSCs) in a mouse model of systemic lupus erythematosus (SLE)-like disease, including the...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will support research to investigate the role of Langerhans cells in regulating lymphatic function and immune tolerance in systemic lupus erythematosus (SLE). The $788,508 award to The Hospital for Special Surgery Fund, Inc. will fund a 5-year study to delineate the mechanisms by which Langerhans...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $558,045 to Beth Israel Deaconess Medical Center, Inc. (Bidmc) to study the role of protein phosphatase 2A (PP2A) in regulating immune cell function and metabolism in systemic lupus erythematosus (SLE). The research aims to determine how PP2A controls enzymes involved in glycolysis and the pentose phosphate pathway,...
The University of Massachusetts Medical School was awarded a $494,929 Project Grant from the National Institute of Allergy and Infectious Diseases to study the role of Toll-like receptors, type II interferon and type III interferon in a murine model of autoinflammation. The grant will support research exploring the effector mechanisms responsible for inducing and regulating cutaneous lupus using genetically modified mice with discriminating mutations. Specifically, the researchers will use...