This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $225,304 to Northwestern University for research on polycystin proteins and their role in autosomal dominant polycystic kidney disease (ADPKD). The primary goals of this project are to: 1) Characterize the functional consequences of ADPKD disease-causing variants in the PKD2 gene using...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research, provides $587,212 to the University of Alabama at Birmingham (UAB) to conduct research on the role of the CDKN1A (P21) gene in polycystic kidney disease (PKD). The goal of the research is to determine how abnormal regulation of the P21 gene, which is involved in cell cycle control and tissue repair, contributes...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $1,472,604 to support research on cyst induction and growth in autosomal dominant polycystic kidney disease (ADPKD). The award was granted to the Children's Hospital Medical Center in Cincinnati, Ohio, and will fund a research project from August 2024 through May 2029. The key objectives are to investigate...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is funding research to investigate intracellular cholesterol biosynthesis as a regulator of polycystic kidney disease (PKD) progression. The $504,621 award to the University of Texas Southwestern Medical Center will support a 5-year research project to: 1) determine if reducing...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $176,244 to The Regents of the University of California, San Francisco (UCSF) to support a 5-year research and training plan. The goal is to prepare Dr. Gabriel Loeb to lead an independent academic research program focused on understanding the mechanisms underlying ciliary...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $640,001 to Yale University to conduct research on the mechanisms and function of the protein Polycystin-1 (PC1) in the context of autosomal dominant polycystic kidney disease (ADPKD). The key objectives are to: 1) determine if a specific 200 amino acid fragment of PC1 can...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $135,582 Project Grant (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) to the University of Oklahoma Health Sciences Center to construct a single-cell atlas of mouse and human cells in autosomal dominant polycystic kidney disease (ADPKD). The project aims to understand how molecular and cellular pathways found in ADPKD patients correlate to mouse models, and to identify inter-...
The University of Pittsburgh received a $198,750 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) to develop a rapid, quantitative platform using yeast to classify how approximately 70 identified mutations in the polycystin-1 (PC1) protein disrupt channel activity with PC2. This research aims to provide new reagents and assays to the scientific and PKD (polycystic kidney disease) community to study the molecular defects of PC1 mutants. The...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $223,918 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the University of Oklahoma Health Sciences Center. The purpose of this 20-month grant, awarded on September 28, 2024, is to study niche filling as a means to achieve long-term, kidney-specific depletion of resident macrophages in order to slow the progression of autosomal dominant polycystic...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is funding research to investigate the role of the FBW7 gene in the development of cystic kidney diseases. The $973,272 award to the University of Oklahoma Health Sciences Center aims to enhance the understanding of cellular mechanisms underlying cystogenesis, fibrosis, and tubular degeneration in...