The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a 5-year, $115,288 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the University of North Carolina at Chapel Hill (UNC-CH). The grant supports research led by Dr. Joseph Burclaff, a mentored early-career investigator, to study how the transcription factor SOX9 regulates mitochondrial metabolism and pro-inflammatory signaling in human intestinal...
This $148,568 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will fund research to elucidate the mechanisms of Notch signaling in intestinal stem cells and their niche cells. The research aims to define how intestinal stem cells maintain Notch signaling and self-renewal in the absence of Paneth cells, as well as the role of Notch-dependent...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $502,752 to The Washington University in St. Louis to investigate the role of endoplasmic reticulum stress in innate lymphoid cells and their relationship to inflammatory bowel disease. The 5-year research program, led by Siyan Cao, M.D., Ph.D., seeks to elucidate the mechanistic links between cellular...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research to functionally characterize the endothelial cell niche for hematopoietic stem cells. The $696,870 grant, awarded on Aug 1, 2024, will enable The Children's Hospital Corporation, doing business as Boston Children's Hospital, to examine vascular reprogramming in adults...
This federal Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA program 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research, supports research to understand the mechanisms regulating epithelial-mesenchymal crosstalk during intrahepatic bile duct (IHBD) development and its potential role in IHBD paucity diseases. The total funding amount is $689,050, with an award date of July 15, 2024 and an ultimate completion...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will provide $664,163 to the Icahn School of Medicine at Mount Sinai to investigate the role of CD39 expression on gamma delta intraepithelial lymphocytes (gd IELs) in maintaining intestinal mucosal homeostasis and preventing inflammatory bowel disease (IBD) relapse. The research aims to elucidate...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) is designed to elucidate the role of deep crypt secretory (DCS) cells in colonic inflammation and tissue repair. The $551,112 award, which runs from September 2024 to June 2029, will support research at Children's Hospital Los Angeles to: 1) test whether impaired DCS cell responses...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $493,470 to the University of Arizona to conduct research on the impact of the Aim2 gene on intestinal stem cell differentiation during inflammation. The research aims to identify novel innate immune targets, cellular signaling pathways, and microbial triggers that can redirect...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research to investigate the epigenetic regulation of intestinal tuft cells and how the microbiota can instruct their development and function. The $627,541 award will be provided to the Childrens Hospital Medical Center in Cincinnati, Ohio over the period of August 1, 2024...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research to investigate the role of epigenetic memory in intestinal stem cell (ISC) function and regeneration. The award provides $364,324 in funding to The Regents of the University of California, San Francisco (UCSF) from July 2024 to March 2027. The research aims to characterize...